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雄激素受体和Wnt信号通路在前列腺癌中的作用 被引量：1

Roles of androgen receptor and Wnt signaling pathway in prostate cancer
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摘要 Wnt信号通路的异常激活在大部分肿瘤(如前列腺癌)的发生发展中具有十分重要的作用;前列腺癌的发生发展和雄激素非依赖性前列腺癌(androgen-independent prostate cancer,AIPC)的转化关键在于雄激素受体(androgen receptor,AR),AR信号通路是前列腺癌研究的主要目标。AR信号通路受许多信号通路的影响,本文主要对Wnt信号通路、AR及其相互作用在前列腺癌中的作用作一综述。 Abnormal activation of Wnt signaling pathway plays an important role in the development and progression of prostate cancer; androgen receptor （AR） is the key for the transformation of androgen-independent prostate cancer （AIPC）, and AR signaling pathway is now the focus of prostate cancer research. Many signal pathways can affect AR signaling pathway; in this paper we review the Wnt signaling pathway, androgen receptor and their crosstalk in prostate cancer.
作者 盛海波 徐斌 梁菁菁 刘善荣
机构地区 第二军医大学长海医院泌尿外科 第二军医大学长海医院内分泌科 第二军医大学长海医院中心实验室
出处 《第二军医大学学报》 CAS CSCD 北大核心 2010年第11期1244-1246,共3页 Academic Journal of Second Military Medical University
关键词 雄激素受体 WNT信号通路 前列腺肿瘤 androgen receptors Wnt signaling pathway prostatic neoplasms
分类号 R737.25 [医药卫生—肿瘤]
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参考文献24

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同被引文献12

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第二军医大学学报
2010年 第11期

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