摘要
目的:探讨挤出滚圆法制备微丸的过程中物料粉体学性质对成型性的影响。方法:以当归补血汤提取物为模型药物,考察提取物粉末粒径及加入辅料润湿后所得软材的黏附性对微丸成型性的影响。结果:当归补血汤提取物粉末粒径在一定范围内越小其微丸成型性越好,软材黏附系数需要在特定的范围内才能制备成圆整度较好的微丸。结论:物料的粉体学性质影响了中药微丸的成型性。
Objective： To investigate the correlation of powder properties and formability of traditional Chinese medicine pellets prepared by extrusion/spheronization.Method： The present effort was designed to evaluate the effects of the characters of powder on pellets formation by extrusion-spheronization,taking Danggui Buxue decoction extracts as a model drug and microcrystalline cellulose（MCC） as an ideal balling material for extrusion-spheronization.Result： The diameter of powder had correlation with the plane critical angle of pellets in a certain scope and the sticky coefficient of wet mass affected roundness of pellets.Conclusion： Properties of powder have influence on formability of traditional Chinese medicine pellets.
出处
《中国中药杂志》
CAS
CSCD
北大核心
2010年第23期3136-3139,共4页
China Journal of Chinese Materia Medica
基金
江苏省中医药领军人才专项(2006)
国家中医药管理局中医药科学技术研究专项(06-07ZQ05)
江苏省中医药局中医药科技技术研究专项(LZ09061)
关键词
粉体学性质
中药微丸
成型性
挤出滚圆
properties of powder
pellets
formability
extrusion-spheronization
