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复方樟柳碱对大鼠视网膜缺血再灌注损伤的保护作用 被引量:4

Protection effect of compound anisodine in rats with retinal ischemia-reperfusion injury
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摘要 目的:探讨复方樟柳碱对大鼠视网膜缺血再灌注损伤的治疗作用。方法:将成年雌性Wistar大鼠随机分成正常对照组,造模组和复方樟柳碱组,每组10只。采用前房灌注升高眼压制作急性视网膜缺血模型。观察1,3,7d视网膜电图a波b波的恢复情况。每组随机取2只大鼠造模眼球光镜、电镜下观察视网膜形态结构的变化,以及神经节细胞线粒体的变化。结果:复方樟柳碱组较造模组神经节细胞线粒体肿胀程度轻,b波明显恢复,同造模组与正常组间b波的恢复比较差异有显著统计学意义(P<0.01)。结论:复方樟柳碱可减轻大鼠视网膜缺血再灌注损伤,有神经细胞保护作用。 AIM: To investigate the therapeutic effect of compound anisodine in rats with retinal ischemia-reperfusion injury. METHODS: Totally 30 adult female rats were divided into three groups at random. Group 1(n=10):normal control;group 2(n=10):high intraocular pressure (IOP)induced ocular ischemia model; group 3(n=10):compound anisodine treatment. At the 1 day, 3,7 days the recovery condition of a-wave and b-wave by electroretinogram were observed in each group respectively. The morphology of retinal were observed by light microscope(n=2) in each group randomly. Retinal morphology and ganglion cells mitochondrion were evaluated by electron microscope. RESULTS: In our research, the recovery of b-wave in group 3 were better than that in group 1 and 2, and showed significant difference(P〈0.01) .In addition, group 3 ganglion cells mitochondrion swelling were lighter than that in group 2. CONCLUSION: Compound anisodine can ameliorate the retinal ischemia-reperfusion injury in rats. 
作者 赵易 陈丽娟
出处 《国际眼科杂志》 CAS 2010年第12期2268-2270,共3页 International Eye Science
关键词 缺血再灌注 复方樟柳碱 ischemia-reperfusion compound anisodine
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参考文献5

  • 1Grozdanic SD,Sakaguchi DS,Kwon YH,et al.Functional characterization of retina and optic nerve after acute ocular ischemia in rats.Invest Ophthalmol Vis Sci 2003;44(6):2597-2605.
  • 2Osborne NN,Casson Pal,Wood JP,et al.Retinal ischemia:mechanisms of damage and potential therapeutic strategies.Prog Retin Eye Res 2004;23(1):91-147.
  • 3Gilgun-Sherki Y,Rosenbaum Z,Melamed E,et al.Antioxidant therapy in acute central nervous system injury:current state.Pharmacol Rev 2002;54(2):271-284.
  • 4Celebi S,Dilsiz N,Yilmaz T,et al.Effects of melatonin,vitamin E and octreotide on lipid peroxidation during ischemia-reperfusion in the guinea pig retina.Eur J Ophthalmol 2002;12(2):77-83.
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