摘要
目的:研究膀胱尿路上皮癌中Snail与E-cadherin的表达,并探讨其与膀胱癌复发的关系。方法:应用免疫组化方法,检测40例膀胱尿路上皮癌组织和20例癌旁组织中Snail、E-cadherin的表达情况,并分析与临床病理资料的关系。结果:膀胱尿路上皮癌组织中Snail的阳性率(80%)显著高于癌旁组织(45%)(P<0.05),Snail的表达与膀胱尿路上皮癌不同临床分期、病理分级、肿瘤数量、远处转移及复发有关(P<0.05);膀胱尿路上皮癌组织中E-cadherin的阳性率(27.5%)显著低于癌旁组织(65%)(P<0.05),E-cadherin的表达与膀胱尿路上皮癌不同临床分期、病理分级、肿瘤数量及远处转移有关(P<0.05)。膀胱尿路上皮癌组织中Snail与E-cadherin的表达呈负相关(P<0.05)。结论:Snail高表达及E-cadherin低表达与膀胱尿路上皮癌的浸润和转移密切相关,Snail有可能作为膀胱尿路上皮癌复发的重要生物学标志。
Objective：To investigate the expression of Snail and E-cadherin in bladder urothelial carcinoma and evaluate their relationships with tumor recurrence.Methods：Immunohistochemical method was used to detect the expression of Snail and E-cadherin proteins in 40 cases of bladder urothelial carcinoma tissue and 20 cases of the para-cancerous mucosa.Results：The positive rate of Snail in bladder urothelial carcinoma was 80%,which was significantly higher than that in para-cancerous mucosa（45%,P 0.05）.The expression of Snail was significantly related with the differential clinical stage,pathological degree,tumor quantity,distant metastasis and tumor recurrence（P 0.05）.The positive rate of E-cadherin in bladder urothelial carcinoma was 27.5%,which was significantly lower than that in para-cancerous mucosa（65%,P 0.05）.The expression of E-cadherin was significantly related with the differential clinical stage,pathological degree,tumor quantity and distant metastasis（P 0.05）.There was negative correlation between expression of Snail and E-cadherin in bladder urothelial carcinoma.Conclusion：The high expression of Snail and low expression of E-cadherin in bladder urothelial carcinoma are involved in the processes of invasion and metastasis of bladder urothelial carcinoma.Snail might be important biological marker for recurrence of bladder urothelial carcinoma.
出处
《现代肿瘤医学》
CAS
2010年第12期2422-2425,共4页
Journal of Modern Oncology
