摘要
Fulminant type 1 diabetes is a recently discovered subtype of idiopathic type 1 diabetes, defined as diabetes with an extremely rapid process of β-cell destruction and progression to hyperglycemia and ketoacidosis. In this report, we present a case of fulminant type 1 diabetes in a 45-year-old Chinese woman, along with a review of the literature. The patient presented with sudden onset of polydipsia and polyuria after flu-like symptoms. Findings on admission included a high blood glucose level and ketoacidosis, but normal HbAlc level. The C-peptide stimulation test showed severe impairment of insulin secretion. Autoantibodies to glutamic acid decarboxylase （GAD） were negative. These results are compatible with the diagnosis of fulminant type 1 diabetes. Human leukocyte antigen-DR7 （HLA-DR7） was available in this case. It is concluded that this rapidly progressing type of diabetes exists, and we propose that HLA-DR7 might be predisposed to fulminant type 1 diabetes in Chinese patients.
Fulminant type 1 diabetes is a recently discovered subtype of idiopathic type 1 diabetes,defined as diabetes with an extremely rapid process ofβ-cell destruction and progression to hyperglycemia and ketoacidosis.In this report,we present a case of fulminant type 1 diabetes in a 45-year-old Chinese woman,along with a review of the literature.The patient presented with sudden onset of polydipsia and polyuria after flu-like symptoms.Findings on admission included a high blood glucose level and ketoacidosis,but normal HbA1c level.The C-peptide stimulation test showed severe impairment of insulin secretion.Autoantibodies to glutamic acid decarboxylase(GAD) were negative.These results are compatible with the diagnosis of fulminant type 1 diabetes.Human leukocyte antigen-DR7(HLA-DR7) was available in this case.It is concluded that this rapidly progressing type of diabetes exists,and we propose that HLA-DR7 might be predisposed to fulminant type 1 diabetes in Chinese patients.
