摘要
目的研究冠心病患者血尿酸水平升高与凝血功能之间的相关性。方法88例住院患者分为正常组(CO)、稳定型心绞痛组(SA)和急性冠脉综合征(ACS)3组。比较3组患者的血尿酸和凝血功能检测值,分析血尿酸升高与凝血的关联性。结果①血小板α-颗粒膜蛋白(GMP-140):SA和ACS均高于正常对照组,ACS与SA无差异(P>0.05);②血管性假性血友病因子(vWF):SA和ACS均高于正常对照组,ACS高于SA(P<0.05);③纤溶酶原激活物抑制物-1(PAI-1):SA和ACS均高于正常对照组(P<0.05),ACS与SA无差异(P>0.05)。Logistic逐步回归分析表明:vWF、PAI-1、GMP-140与血尿酸相关。结论血尿酸升高可通过损害血管内皮功能、激活血小板、改变凝血功能、引起炎症反应导致冠心病的发生。
【Objective】To study the dependablity on blood clotting function and blood uric acid level of coronary heart disease.【Methods】Eighty-eight patients were divided into three groups：control group（CO）,stable angina group（SA） and acute coronary syndrome group（ACS）.【Results】Comparing all index between three groups：① GMP-140：SA and ACS groups are higher than CO groups.There is no difference between SA group and ACS group（P〉0.05）.②vWF：SA and ACS groups are higher than CO groups.ACS group is higher than SA group（P〈0.05）.③ PAI-1：SA and ACS groups are higher than CO groups（P〈0.05）.There is no different between SA group and ACS group（P〉0.05）.Logistic stepwise regression analysis indicates：the related factor with UA are vWF,PAI-1,GMP-140.【Conclusion】Hyperuricemia can induce CHD by damaging blood vessel endothelium function,activating platelet and changing coagulation.
出处
《中国现代医学杂志》
CAS
CSCD
北大核心
2010年第3期448-450,共3页
China Journal of Modern Medicine
关键词
冠心病
血尿酸
凝血功能
相关性研究
coronary heart disease
blood uric acid
blood clotting function
dependablity study
