摘要
血栓栓塞性疾病是危害人类健康的主要问题。在血栓形成前,血液出现一系列异常现象,即所谓血栓前状态(prethrombotic state,PTS)。有关血栓前状态的实验室诊断是当前血液学面临的重大研究课题,虽然有数十种检测项目可供选择,但还没有找到一致公认的特异性和敏感性均令临床满意的指标。作者提出血管性血友病因子(von Willebrand factor,vWF)、血小板颗粒膜蛋白-140(GMP-140)、血小板聚集试验(PAgT)、血液粘度测定、凝血酶原片段1+2(F1+2)、纤维蛋白肽A/B(FPA/B)、活化蛋自C抵抗试验(APCRT)等7项检测项目可做为血栓前状态的诊断指标。
Thromboem-bolistic dis-eases are threatenning human' s lives. Be-fore the thrombosis, blood shows a series of abnormal phenomena, which are called prethrombotic state (PTS) . The laboratory
diagnosis of PTS is the focus of research now. Although there are about a few dozens tests being used now, no common index of specificity and sensitivity has been reached. Our research suggests that the following seven tests: von Willebrand factor (vWF), granule membrane protetn (GMP-140), platelet aggregation test (PAgT), blood vis-cosity test, prothrombin fragment 1 +2(F1 + 2), fibrin peptide A or B (FPA or FPB), acti-vated protein C resistance test (APCRT) can be used as the diagnosis indexes. The stan-dardization of these tests is also of great im-portance.
