摘要
目的 探讨舍曲林联合奥氮平治疗抑郁症的临床疗效和安全性.方法 将40例抑郁症患者随机分为两组,每组20例,两组均口服舍曲林治疗,研究组在此基础上晚间口服奥氮平治疗,观察6周.于治疗前及治疗1周、2周、4周、6周末采用汉密顿抑郁量表评定临床疗效,副反应量表评定不良反应. 结果治疗后两组汉密顿抑郁量表总分均较治疗前有显著下降（P〈0.01）,两组间比较均无显著性差异（P〉0.05）. 治疗6周末研究组显效率89.5%、有效率100%;对照组分别为70.0%、90.0%;研究组显效率、有效率略高于对照组,但无显著性差异（χ2=2.153、1.903,P〉0.05）.两组不良反应均轻微,多发生在治疗初期,随着治疗时间的延续可逐渐缓解或消失. 结论 舍曲林联合奥氮平治疗抑郁症效果显著,起效快,安全性高,依从性好,优于单用舍曲林治疗.
Objective To explore the clinical efficacy and safety of sertraline plus olanzapine in the treat- ment of depression. Methods Forty depression patients were randomized to two groups of 20 ones each, both groups took orally sertraline, and research group was plus oral olanzapine q. n. for 6 weeks. Clinical efficacies were assessed with the Hanmilton Depression Scale（HAMD） and adverse reactions with the Treatment Emergent Symptom Scale （TESS） before treatment and at the end of the 1st, 2nd, 4th and 6th week. Results After treatment, the HAMD total scores of both groups lowered more signifcantly com- pared with pretreatment （P〈0. 01）, there were no significant differences in group comparisons （P〈0.05）. At the end of the 6th week, obvious effective and effective rates were 89.5% and 100% in the re- search and 70.0% and 90.0% in the control group respectively, which showed no significant differences （χ2=2. 153, 1. 903; P〉0.05）. Adverse reactions of both groups were mild, mainly took place in the ini- tial stage of treatment, and gradually relieved or disappeared with the treatment. Conclusion Sertraline plus olanzapine has an evident effect, takes effect more rapidly, has higher safety and better compliance than sertraline only in depression.
出处
《临床心身疾病杂志》
CAS
2010年第6期515-516,共2页
Journal of Clinical Psychosomatic Diseases
