摘要
目的评价立普妥(阿托伐他汀)联合美卡素(替米沙坦)对血脂正常的早期糖尿病肾病(DN)患者疗效的影响。方法 76例血脂正常的糖尿病肾病患者,随机分为治疗组(给予立普妥20mg qn,同时给予美卡素80mg qd,n=38)以及对照组(单用美卡素80mg qd,n=38)。于开始治疗前以及药物治疗3个月后,行尿白蛋白、血肌苷(Scr)、血脂、血压、肌酸激酶、ALT、AST等检测。结果两组患者血压都有降低,但两组差异无统计学意义(P>0.05),两组血脂变化差异无统计学意义(P>0.05),治疗组尿白蛋白显著下降(P<0.01),对照组尿白蛋白下降(P<0.05),治疗组治疗后尿蛋白下降更为显著,治疗组效果优于对照组(P<0.05)。结论立普妥联合美卡素降尿白蛋白优于单用美卡素,对DN患者有独立于血脂之外的肾脏保护作用,安全性好。
Objective To evaluate the effects of atorvastatin and telmisartan on treatment of early diabetes and nephrosis with normal lipid.Methods 76 patients with early diabetes and nephrosis with normal lipid were randomized into treatment group（atorvastatin together with telmisartan,n=38） and control group（telmisartan,n=38）.The changes of urinary albumin,serum creatinine,lipid,blood pressure,creatine,ALT and AST were tested before and after therapy.Results The blood lipid in both groups decreased（P0.05）.The urinary albumin in treatment group,decreased significantly（P0.01）,but the urinary albumin in control group did not decrease significantly（P0.05）.After medical treatment in treatment group,the decrease of urinary albumin was more significant and the treatment outcome outweighed the control group（P0.05）.Conclusion Urinary albumin decreased more significantly by administrating atorvastatin together with telmisartan than telmisartan only.
出处
《西部医学》
2010年第12期2218-2220,共3页
Medical Journal of West China
关键词
阿托伐他汀
替米沙坦
早期糖尿病肾病
尿白蛋白
血脂
Atorvastatin
Telmisartan
Early diabetes and nephrosis
Urinary albumin
Blood lipid
