摘要
目的 研究绝经前系统性红斑狼疮（SLE）病人动脉粥样硬化的发生情况,并探讨心血管疾病危险因素在此过程中的作用.方法 采用颈动脉超声检测56例绝经前SLE病人（SLE组）及42例健康女性（对照组）颈部动脉粥样硬化斑块发生情况.所有入选对象均无临床心血管疾病史.并对血清血管内皮生长因子（VEGF）、总胆固醇（TC）、三酰甘油 （TG）、低密度脂蛋白（LDL）、高密度脂蛋白（HDL）、脂蛋白a等与颈动脉斑块之间的关系进行研究.结果 SLE组中有12例（21.4%）存在颈动脉斑块,而在对照组中仅1例存在颈动脉斑块（2.3%）,两组比较差异有显著意义（χ2=7.57,P〈0.01）.与对照组相比,SLE组血清VEGF、TC、TG、LDL水平明显增高,而HDL水平明显降低（t=2.54～3.35,P〈0.05、0.01）.SLE病人中与无颈动脉斑块组比较,有颈动脉斑块组的病程明显延长,血清VEGF水平明显升高,HDL水平则明显降低（t=3.01～3.43,P〈0.01）.结论 绝经前SLE病人颈动脉粥样硬化斑块的发生率明显增高.SLE病程长及高VEGF、低HDL水平可能是SLE病人发生颈动脉斑块的危险因素.
Objective To investigate the prevalence of atherosclerosis and its associated risk factors in premenopausal women with systemic lupus erythematosus （SLE）. Methods The prevalence of atherosclerotic plaque （AP） on the neck in 56 premenopausal women with SLE and 42 healthy controls were examined by ultrasonography. All the participants had no a history of cardiovascular disease. The relationship between the cardiovascular risk factors, such as VEGF, TC, TG, LDL, HDL, Lp（a） and the carotid plaque was studied. Results Carotid plaques were found in 12 SLE patients （21.4%）, while only one in the healthy control subjects （2.3%）. Compared with those of the controls, SLE patients had a significantly higher levels of VEGF, TC, TG, LDL and lower level of HDL （t=2.54--3.35;P〈0.05,0.01）. SLE patients with carotid plaque had a longer course of disease, significantly higher levels of VEGF, and lower levels of HDL, compared with that of the SLE patients without carotid plaque （t= 3.01--3.43, P〈0.01）. Conclusion Premenopausal SLE patients present a higher prevalence of carotid AP than healthy controls. Longer course of disease, higher levels of VEGF and lower levels of HDL might he the risk factors of carotid plaque formation in the patients.
出处
《青岛大学医学院学报》
CAS
2010年第6期497-499,共3页
Acta Academiae Medicinae Qingdao Universitatis
关键词
红斑狼疮
系统性
动脉硬化
颈动脉疾病
危险因素
lupus erythematosus, systernic
arterosclerosis
carotid artery diseases
risk factors
