摘要
目的 研究血小板激活因子拮抗剂ＢＮ５２０２１对大鼠缺血再灌注损伤肝脏的影响。方法 将大鼠分成３组，对照组未行缺血及药物治疗，缺血再灌注损伤组，ＢＮ５２０２１治疗组，比较各组血清谷丙转氨酶（ＡＬＴ）、谷草转氨酶（ＡＳＴ）、碱性磷酸酶（ＡＫＰ）、γ－ＧＴ等各项指标，肝脏的细胞能荷。结果 用血小板激活因子拮抗剂治疗组血清ＡＬＫ、ＡＳＴＩ、ＡＫＰ、γ－ＧＴ均较缺血再灌注损伤组显著降低，能荷水平明显升高。结论 表明ＢＮ５２０２１用于大鼠肝脏缺血再灌注治疗可减少肝脏的损害，提示血小板激活因子（ＰＡＹ）对肝脏缺血再灌注损伤的发生起一定作用，ＢＮ５２０２１有可能用于肝脏缺血再灌注损伤的治疗。
Objective The effects of platelet-activating factor antagonist(Anti - PAF) BN 52021 on ischemia reperfusion injury of rat liver were studied. Methods Rats were divided into 3 groups. (the normal control group, the ischemia -- reperfusion injury group and the anti -- PAF treatment group) Serum ALK. AST. AKP. γ-- GT and hepatic energy charge were compared. Results The anti -- PAF treatment group's serum levels of ALK .AST .AKP and γ -- GT were significantly lower than the ischemia -- reperfusion injury group energy charge level was significantly higher with Anti -- PAF treatment. Conclusions in conclusion anti -- PAF BN 52021 treatment at reperfusion decreased and functional damage of rat liver subjected to ischemia -- reperfusion. This implies that PAF plays a role in liver ischemia reperfusion injury. Anti- PAF BN 52021 may be useful in the treatment of hepatic ischemia- reperfusion injury.
出处
《洛阳医专学报》
1999年第1期20-22,共3页
Journal of Luoyang Medical College
