摘要
目的:观察尼卡地平iv gtt治疗重度高血压的降压疗效及安全性.方法:多中心入选54例原发性重度高血压并接受尼卡地平治疗12h.观察临床症状、不良反应、BP和HR变化.结果:总有效率100%,用药后5min血压即明显下降,30min达显效水平,1.5h达最大降压效应并平稳维持至用药结束;达目标血压的药物滴速、累积量、时间分别为(55±28)μg/min、(2.10±1.52)mg、(38±19)min.维持目标血压的药物滴速为(49±25)μg/min,12h总量为(35.5±10.2)mg;不良反应发生率为 9.3%.结论:尼卡地平iv gtt能快速、有效地控制重度高血压的血压水平.
AIM: To research the efficacy and safety of intravenous nicardipine in the treatment of patients with severe essential hypertension. METHODS:In a multicenter study, fifty-four patients with severe essential hypertension met the entry criteria and received in-travenous nicardipine. The efficacy and safety of intravenous nicardipine was observed in the control of blood pressure. RESULTS: Remarkable therapeutic response was achieved in all of the patients. Blood pressure apparently decreased after 5 min of the administration,reached the markedly effective level after 30 min and the effective peak after 1. 5 h. The mean time and infusion rate for reaching required blood pressure level were (38±9) min and (55±8) μg/min, respectively. Blood pressure control was sustained with intravenous nicardipine of (49 ±25) μg/min during a prolonged maintenance infusion period of 12 h. The increase in heart rate of ≥5 bpm and of ≥10 bpm was seen in 59% of and 39% of the patients,respec-tively.The total incidence of adverse effects was 9. 3%,including headache(5. 6% ) .palpita-tion(5. 6%),blush(3. 7%) and overrapid reduction of blood pressure (1. 9%). In all these patients except the one with overrapid reduction of blood pressure, which was resolved fol-lowing discontinuation of nicardipine therapy, adverse effects could be tolerable. None of these patients during nicardipine therapy had exhibited arrhythmias, conduction blockades and ST segment changes indicative of myocardial ischemia. No clinically important changes in laboratory biochemical variables were found. CONCLUSION:These findings indicate that in-travenous nicardipine can rapidly, effectively and safely control blood pressure in patientswith severe essential hypertension.
出处
《中国临床药学杂志》
CAS
1999年第2期67-69,共3页
Chinese Journal of Clinical Pharmacy
