摘要
目的:探讨抗-IFN与IFN治疗病毒性肝炎疗效的关系。方法:采用ELISA法检测32例慢性病毒性肝炎患者治疗前后血清抗-IFN。结果:IFN治疗后3个月、6个月,抗-IFN阳性率分别为28.1％、31.1％,其阳性率明显高于治疗前(6.3％),使用不同类型IFN,产生抗-IFN情况也有差别。用IFN治疗3个月、6个月后,抗-IFN阳性者,HBV-DNA或HCV-RNA阴转率分别为22.2％(2/9)、20.0％(2/10);而阴性者,则分别为43.4％(10/23)、54.5％(12/22),后者的阴转率较前者高,治疗前抗-INF已阳性的2例病人HBV-DNA均没有阴转。结论:抗-IFN可能是影响干扰素疗效的因素。
Aim: To study the relationship of anti-IFN formation on the therapeutic effect of IFN. Method: Anti-IFN was detected by using ELISA method in the sera from 32 patients with chronic hepatitis. Results: The results indicated that the incidences of anti-IFN in the patients who had been treated with IFN for 3 and 6 months were 28.1 % and 31. 1% , respectively. The positive rates were higher than that in the same patients before treatment (6. 3%). The frequencies of anti-IFN were related with the subtypes of IFN used. After the treatment for 3 and 6 months. 22. 2% (2/ 9) and 20. 0% (2/10) patients with anti-IFN positive had disappearance of HBV-DNA or HCV-RNA, it was lower than that of anti-IFN negative patients. Two patients whose antibody positive before treatment, the HBV-DNA did not disap-perance. Conclusion: It is concluded that anti-IFN was one of the factors affecting the response to IFN therapy.
出处
《中西医结合肝病杂志》
CAS
1999年第2期5-7,共3页
Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases
