摘要
目的:观察乳果糖治疗亚临床型肝性脑病(SHE)的临床疗效。方法:通过对473名健康人进行数字连结试验(NCT)、数字符号试验(DST)检测,获得不同年龄、不同文化程度人群的相应正常值。对154例肝硬变病人进行上述2项智力测验,任何1项异常别诊为SHE,共发现86例SHE病人。其中,48例按常规治疗肝硬化并服用乳果糖(治疗组),38例(对照组)不用乳果糖,其他处理同治疗组。疗效判断:治疗1个月后每例患者再次行2项智力测验,有1项测验由异常转为正常则判为好转。同时进行肝功能分级(Pugh-Child改良分级法)。结果:NCT、DST好转率在治疗组分别为44.4％与60.0％,均显著高于对照组(22.9％与0％)(P<0.05),治疗组中26例智力测验恢复正常,好转率54.2％,明显高于对照组28.9％;治疗组肝功能分级构成比在治疗1个月后有所改善,但无统计学意义。结论:乳果糖对SHE有明显疗效,可作为防治SHE的一线首选药物。
Aim: To evaluate the clinical ettect of lactulose in the treatment of subclinical hepatic encephalopathy (SHE). Method: 473 healthy individuals were given number-connecting-test (NCT) and digital-symbol-test (DST) to achieve the nomal values of different ages and cultures. 154 patients with liver cirrhosis were given both of the same two intellectual tests and would be diagnosed as SHE if either of them was abnormal. 86 SHE cases were divided into two groups: therapeutic group of 48 cases was with routine treatment for cirrhosis.adding lactulose,control group of 38 cases only with routine treatment. Effect judgement: One month later, each case was accepted the same two intellectual tests again. it was not judged to be effective unless at least one test changed to nomal from the abnormal, meanwhile liver function degree was graded according to Pugh-child grading method. Results: The effective rates of NCT and DST of therapeutic group were 44. 4 % and 60. 0 % respectively both significantly higher than those of control group. which were 22. 9% and 0% accordingly (P<0. 05). The intellectual test of 26 cases in therapeutic group were changed to nomal, the effective rate was 54. 2% and much higher than that of control group, which was 28. 9%. In the therapeutic group the constituting rates of liver functional grade were improved after one month of treatment however there was no statistic significance. Conclusion: Lactulose is obviously effective in treating SHE and is suggested to be the first choice for preventing and treating SHE.
出处
《中西医结合肝病杂志》
CAS
1999年第2期13-15,共3页
Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases
基金
课题编号EK980415
关键词
肝性脑病
乳果糖
疗效
Subclinical Hepatic Encephalopathy Lactulose Intellectual Test Liver Cirrhosis
