摘要
目的:探讨P16、CyclinD1蛋白在子宫肉瘤中表达的意义,以揭示其发病机制并为其早期诊断及治疗提供依据。方法:采用免疫组化S-P法检测P16、CyclinD1在62例子宫肉瘤中的表达,以20例子宫肌瘤作对照。结果:①不同病理类型子宫肉瘤分别与子宫平滑肌瘤比较,仅子宫平滑肌肉瘤中P16的表达差异有统计学意义(P<0.05)。②P16、CyclinD1在子宫肉瘤中的表达无明显相关性(rs′=-0.088 3,P>0.05)。结论:①P16可作为子宫平滑肌肿瘤良恶性鉴别的重要指标。CyclinD1在子宫肉瘤发生中可能是一个早期分子事件,其过表达是细胞增殖失控的普遍现象。②P16与CyclinD1交叉共表达,揭示了肿瘤发生过程中基因表达的复杂性,P16表达缺失与CyclinD1过表达可单独或共同参与子宫肉瘤的形成。
Objective：To explore the significances of P16 and CyclinD1 protein expressions in uterine sarcoma,reveal the mechanism and provide a basis for early diagnosis and treatment.Methods：Immunohistochemical S-P method was used to detect the expression levels of P16 and CyclinD1 in 62 cases with uterine sarcoma,20 cases with hysteromyoma were selected as control group.Results：There was significant difference in expression of P16 among uterine leiomyosarcoma when uterine sarcoma of different pathological types were compared with uterine leiomyoma（P〈0.05）.There was no correlation between P16 expression and CyclinD1 expression in uterine sarcoma（rs′=-0.088 3,P〉0.05）.Conclusion：P16 can be used as an important marker for differentiation of uterine smooth muscle tumors;CyclinD1 may be an early molecular event in occurrence of uterine sarcoma,and its over-expression is a general phenomenon in out of control of cell proliferation;the co-expression of P16 and CyclinD1 reveals the complex of gene expression during the genesis of uterine sarcoma,expression deletion of P16 and over-expression of CyclinD1 may participate in the genesis of uterine sarcoma alone or altogether.
出处
《中国妇幼保健》
CAS
北大核心
2010年第34期5099-5101,共3页
Maternal and Child Health Care of China
