摘要
目的观察在欧美人群中与前列腺癌(PCa)高度相关的3个基因变异位点rs6983561、rs16901979、rs1447925与我国汉族人PCa的相关性。方法选择我国汉族PCa患者(PCa组)和正常人(对照组)各120例,采用直接测序法对其rs6983561、rs16901979、rs1447925位点单核苷酸多态性(SNP)基因进行检测,分析这3个位点SNP与PCa风险关联性。结果 rs6983561C、rs16901979A等位基因与PCa风险无关联性(OR值分别为1.19、1.13,P均>0.05),rs1447295A等位基因与PCa风险有关联性(OR=1.63,P<0.05)。结论我国汉族人群中rs1447295A等位基因与PCa有关联性,rs1447295A等位基因携带者PCa风险增加。
Objective To determine whether three risk variants were associated with prostate cancer（PCa） risk in Chinese Has population. Methods Its were comprised of 120 PCa patients and 120 healthy controls in Chinese Han population a ease-control study. Cenotyping by direct sequencing was performed for rs16901979, rs6983561 and rs1447295. Results The allele C of rs6983561 and A of rs16901979 were not associated with PCa risk（ odds ratios were 1.19 and 1.13, P 〉 0.05）. The allele A of rs1447295 was significantly associated with PCa risk （odds ratio was 1.63, P 〈 0.05）. Conclusion The variants rs1447295 is associated with PCa risk in Chinese Has population, the allele A of rs1447295 carrying can increase the risk of PCa.
出处
《山东医药》
CAS
北大核心
2010年第46期14-16,共3页
Shandong Medical Journal
关键词
前列腺癌
基因多态性
风险因子
汉族
prostatic neoplasms
genetic polymorphism
risk
Han population
