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肿瘤干细胞和抗肿瘤药物研发思路 被引量：2

Tumor stem cells and strategies for research and development of new anticancer drugs
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摘要 目前有些抗肿瘤药物尽管有较好的近期疗效,然而肿瘤患者单纯依赖化疗通常难以达到长期生存的目的。本文试图从肿瘤干细胞理论解释抗肿瘤药物近期疗效和远期生存之间存在的矛盾,并探讨抗肿瘤药物的研究发展方向。
作者 李月敏 宋三泰 艾军 蒲永东
机构地区 解放军第 军医进修学院临床医学博士后流动站 军事医学科学院附属 河北医科大学四院河北省肿瘤所免疫室
出处 《军医进修学院学报》 CAS 2010年第12期1259-1261,共3页 Academic Journal of Pla Postgraduate Medical School
基金 中国博士后科学基金(20090461439) 河北省自然科学基金(C2009001195)~~
关键词 肿瘤干细胞 抗肿瘤药
分类号 R730.53 [医药卫生—肿瘤]
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参考文献30

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同被引文献82

  • 1钱其军,张琪.肿瘤靶向治疗的现状和展望[J].中国肿瘤生物治疗杂志,2006,13(4):239-242. 被引量：7
  • 2Feng Li,Benjamin Tiede,Joan Massague,Yibin Kang.Beyond tumorigenesis: cancer stem cells in metastasis[J].Cell Research,2007,17(1):3-14. 被引量：86
  • 3陈运贤,朱小玉.肿瘤治疗新目标——肿瘤干细胞[J].中国肿瘤,2007,16(7):518-520. 被引量：3
  • 4Conti CM, Angelucci D, Ferri M, Maccauro G, Caraffa A, Doyle R, et al. Relationship between cancer and psychology: An updated history. J Biol Regul Homeost Agents 2011; 25(3): 331-9.
  • 5Ciurea ME, Georgescu AM, Purcaru SO, Artene SA, Emami GH, Boldeanu MV, et al. Cancer stem cells: Biological functions and therapeutically targeting. Int J Mol Sci 2014; 15(5): 8169-85.
  • 6Reya T, Morrison S J, Clarke MF, Weissman IL. Stem cells, cancer, and cancer stem cells. Nature 2001; 414(6859): 105-11.
  • 7Bu Y, Cao D. The origin of cancer stem cells. Front Biosci (Schol Ed) 2012; 4: 819-30.
  • 8Renan MJ. How many mutations are required for tumorigenesis? Implications from human cancer data. Mol Carcinog 1993; 7(3): 139-46.
  • 9Takao S, Ding Q, Matsubara S. Pancreatic cancer stem cells: Regulatory networks in the tumor microenvironment and targeted therapy. J Hepatobiliary Pancreat Sci 2012; 19(6): 614-20.
  • 10Cheng CY, Hwang CI, Corney DC, Flesken-Nikitin A, Jiang LC, Oner GM, et al. miR-34 cooperates with p53 in suppression of prostate cancer by joint regulation of stem cell compartment. Cell Reports 2014; 6(6): 1000-7.

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军医进修学院学报
2010年 第12期

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