摘要
目的分析抗心律失常药导致室性心律失常的原因。方法应用动态心电图分析187例抗心律失常药致室性心律失常。结果各种抗心律失常药都有不同程度致心律失常不良反应,尤其Ic类抗心律失常药致室心律失常作用较强。结论当左室射血分数降低(LVEF<40%),联合应用利尿剂及/或地高辛,和/或应用抗精神类药物,用药后QT间期离散度增加等都可出现致室性心律失常不良反应。
Objective To analyze the cause of ventricular arrhythmias by antiarrhythmic drugs.Methods 187 cases of ventricular arrhythmias caused by antiarrhythmia drugs by means of dymamic ECG were studied.Results Every kind of antiarrhythmic drugs has proarrhythmic side effects of different levels,particularly,class Ic antiarrhythmic drugs induced strong chamber arrhythmia.Conclusion When the left ventricular ejection fraction decrease （LVEF 40%）,mixed use of drugs like diuretics or digoxin,and increase of QT interval dispersion using after anti-psychotic drugs,may lead to abnormal side effects of ventricular arrhythmia.
出处
《检验医学与临床》
CAS
2010年第22期2462-2463,2465,共3页
Laboratory Medicine and Clinic
