摘要
目的比较甘精胰岛素联合阿卡波糖与门冬胰岛素30治疗成人隐匿性自身免疫性糖尿病(LADA)患者的疗效和安全性。方法 68例确诊为LADA患者随机分为甘精胰岛素加服阿卡波糖组(A组)和单用门冬胰岛素30组(B组),治疗12周后比较两组间血糖控制情况和低血糖发生率。结果 A组餐后2 h血糖、糖化血红蛋白和血糖达标时间比均低于B组(P<0.05),低血糖发生率差异有统计学意义(P<0.05)。结论甘精胰岛素联合阿卡波糖治疗LADA有利于血糖得到安全、全面控制,并且治疗达标时间短,疗效优于单用门冬胰岛素30。
Objective To compare the safety and efficacy of insulin glargine combined with acarbose and insulin aspart 30 in treatment of the latent autoimmune diabetes in adults.Methods 68 latent autoimmune diabetes in adults were randomized divided into two groups.To analysis glycemia,glycosylated hemoglobin and frequency of hypoglycemia between insulin glargine combined with acarbose and insulin aspart in two groups after 12 weeks treatment.Results The 2 h postprandial blood-glucose,glycosylated hemoglobin and time of reaching the standard in insulin glargine combined with acarbose group significantly lower than that of insulin aspart group（P〈0.05）.The incidence rate of hypoglycemia is lower（P〈0.05）.Conclusion The treatment methods of insulin glargine combined with acarbose is safe,fast and humanistic.
出处
《重庆医学》
CAS
CSCD
北大核心
2010年第23期3244-3245,共2页
Chongqing medicine
