摘要
目的观察阿托伐他汀(Atorvastatin)联合还原性谷胱甘肽(reduced Glutathione,GSH)对高脂血症大鼠的抗氧化作用及血脂的影响。方法 SD雄性大鼠40只,随机分成5组,每组8只。A组:给予阿托伐他汀。B组:给予还原型谷胱甘肽。C组:给予阿托伐他汀+还原型谷胱甘肽。D组:高脂血症对照组,给予高脂饲料灌胃。E组:空白对照组,给予普通饲料喂养。结果各药物干预组低密度胆固醇(LDL),甘油三酯(TG),血清总胆固醇(TC),丙氨酸氨基转移酶(ALT),天门冬氨酸氨基转换酶(AST),丙二醛(Malondialdehyd,MDA)水平均低于高脂血症组(P<0.05),高密度胆固醇(HDL),超氧化物歧化酶(Superoxide dismutase,SOD)水平均高于高脂血症组(P<0.05)。C组与A组及B组比较作用更显著(P<0.05)。结论还原型谷胱甘肽具有抗氧化作用外,还具有调脂作用,可能与阿托伐他汀具有协同作用。
Objective To observe the effect of atorvastatin combined with reduced glutathione on lipid metabolism and antioxygenation in hyperlipidemic rats. Methods 40 SD male rats were randomly divided into five groups,each group had 8 cases. Group A（8 cases） were given atorvastatin,group B（8 cases） were given reduced glutathione,group C（8 cases） were given atorvastatin ＋ reduced glutathione,group D（8 cases） were fed with high fatty forage,group E（8 cases） were fed with common animal feed. Results The levels of low density lipoprotein cholesterol（LDL-C） ,triglyceride（TG） ,serum total cholesterol（TC） ,ALT,AST and malondialdehyd（MDA） in the drugs intervention groups were lower than those in hyperlipemia group（P 0.05） ,while the levels of high density lipoprotein cholesterol（HDL-C） ,SOD in the drugs intervention groups were higher than those in hyperlipemia group（P 0.05） . In addition,the effect in group C was more significant than that in group A and group B（P 0.05） . Conclusion Reduced glutathione has the effect on antioxidant and lower cholesterol. Reduced glutathione may have a synergistic effect with atorvastatin.
出处
《临床医学工程》
2010年第12期1-3,共3页
Clinical Medicine & Engineering
基金
广东省心血管用药研究基金(编号:2009X01)
广东省自然科学基金资助项目(编号:0400870)
