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生长分化因子15在心血管疾病中的应用 被引量：4

Application of growth differentiation factor-15 in cardiovascular disease
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摘要 心血管生化标志物（biomarker）是近年随着免疫学和分子生物学技术的发展而提出的一类可检测、可量化的血液生化物质,不仅能从分子水平反映神经激素激活、心肌细胞应激和坏死以及细胞外基质重塑等不同心血管疾病病理生理机制,而且可准确、敏感地评价早期、低水平的损害,在心血管疾病的诊断、治疗和预后方面具有重要意义.近年研究发现,生长分化因子15（growth differentiation factor-15,GDF-15）除在类风湿性关节炎[1]、肿瘤[2]和地中海贫血[3]等非心血管系统疾病状态下表达增加,还在心肌缺血/再灌注损伤、氧化应激、炎性因子和心肌压力超负荷等病理过程中发挥抑制心肌细胞凋亡、抗心肌肥厚和心脏扩大等保护性作用,有望成为新的心血管生化标志物之一[4,5].
作者 许愿愿 光雪峰(审校)
机构地区 昆明医学院附属延安医院心内科
出处 《中国心血管病研究》 CAS 2010年第12期950-953,共4页 Chinese Journal of Cardiovascular Research
关键词 生长分化因子15 冠状动脉疾病 心力衰竭 肺栓塞
分类号 R541.4 [医药卫生—心血管疾病] R543.2 [医药卫生—心血管疾病]
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参考文献21

  • 1Brown DA,Moore J,Johnen H,et al.Serum macrophage inhibitory cytokine 1 in rheumatoid arthritis:a potential marker of erosive joint destruction.Arthritis Rheum,2007,56:753-764.
  • 2Bauskin AR,Brown DA,Kuffner T,et al.Role of macrophage inhibitory cytokine-1 in tumorigenesis and diagnosis of cancer.Cancer Res,2006,66:4983-4986.
  • 3Tanno T,Bhanu NV,Oneal PA,et al.High levels of GDF15 in thalassemia suppress expression of the iron regulatory protein hepcidin.Nat Med,2007,13:1096-1101.
  • 4Olechnicki M,Kasprzak K,Goch A.Growth differentiation factor 15-a new marker in heart diseases.Pol Merkur Lekarski,2010,28:470-472.
  • 5刘静,李树青.心肌缺血再灌注损伤诱发细胞凋亡的研究进展[J].中国心血管病研究,2005,3(12):951-953. 被引量：8
  • 6Kempf T,Eden M,Strelau J,et al.The transforming growth factor-beta superfamily member growth-differentiation factor-15 protects the heart from ischemia/reperfusion injury.Circ Res,2006,98:351-360.
  • 7Duong Van Huyen JP,Cheval L,Bloch-Faure M,et al.GDF15 triggers homeostatic proliferation of acid-secreting collecting duct cells.J Am Soc Nephrol,2008,19:1965-1974.
  • 8Schober A,Bottner M,Strelau J,et al.Expression of growth differentiation factor-15/macrophage inhibitory cytokine-1 (GDF-15/MIC-1) in the perinatal,adult,and injured rat brain.J Comp Neurol,2001,439:32-45.
  • 9Moore AG,Brown DA,Fairlie WD,et al.The transforming growth factor-ss superfamily cytokine macrophage inhibitory cytokine-1 is present in high concentrations in the serum of pregnant women.J Clin Endocrinol Metab,2000,85:4781-4788.
  • 10Xu J,Kimball TR,Lorenz JN,et al.GDF15/MIC-1 functions as a protective and antihypertrophic factor released from the myocardium in association with SMAD protein activation.Circ Res,2006,98:342-350.

二级参考文献13

共引文献7

同被引文献28

  • 1梁瀛,牛杰,高炜.生长分化因子-15的心血管作用[J].心血管病学进展,2009,30(6):934-938. 被引量：4
  • 2Bootcov MR, Bauskin AR, Valenzuela SM, et al. MIC-1, a novel macrophage inhibitory cytokine, is a divergent member of Ihe TGF- beta superfamily [ J]. Proc Natl Acad Sci U S A, 1997, 94: 11514-11519.
  • 3Bonaterra GA, Ztigel S, Thogersen J, et al. Growth differentiation factor-15 deficiency inhibils alherosclerosis progression by regulating interleukin-6-dependent inflammatory response to vascular injury [ J ]. J Am Heart Assoc ,2012,1 :e002550.
  • 4Bauskin AR, Brown DA, Kuffner T, et al. Role of maerophage inhibitory cytokine-I in tumorigenesis and diagnosis of cancer[ J]. Cancer Res,2006,66:4983-4986.
  • 5Ago T, Sadoshima J. GDF15, a cardioprotective TGF-beta superfamily protein[ J ]. Circ Res, 2006, 98:294-297.
  • 6Zimmers TA, Jin X, Hsiao EC, et al. Growth differentiation factor-15/macrophage inhibitory eylokine-I induction arier kidney and lung injury[ J ]. Shock, 2005,23:543-548.
  • 7Si Y, Liu X, Cheng M, el al. Growth differentiation factor 15 is induced by hepatitis C virus infection anti regulates hepatocellular careinoma-related genes[ J ]. PLoS 0ne,2011,6 : el 9967.
  • 8Oleehnicki M, Kasprzak K, Goch A. Growth differentiation factor 15-a new marker in heart diseases [ J ]. Pol Merkur l,ekarski, 2010,28:470-472.
  • 9Hsiao EC, Koniaris LG, Zimmers-Koniaris T, el al. Characterization of growth-differentiation factor 15, a transforming growlh factor beta superfamily member induced following liver injury[ J]. Mol Cell Biol,2000,20:3742-3751.
  • 10Brown DA,Breit SN,Buring J,et al.Concentration in plasma of macrophage inhibitory cytokine-land risk of cardiovascular events in women:a nested case-control study.Lancet,2002,359(9324):2159-2163.

引证文献4

二级引证文献12

中国心血管病研究
2010年 第12期

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