期刊文献+

A Hopfield-like hippocampal CA3 neural network model for studying associative memory in Alzheimer's disease

A Hopfield-like hippocampal CA3 neural network model for studying associative memory in Alzheimer's disease
下载PDF
导出
摘要 Associative memory, one of the major cognitive functions in the hippocampal CA3 region, includes auto-associative memory and hetero-associative memory. Many previous studies have shown that Alzheimer's disease (AD) can lead to loss of functional synapses in the central nervous system, and associative memory functions in patients with AD are often impaired, but few studies have addressed the effect of AD on hetero-associative memory in the hippocampal CA3 region. In this study, based on a simplified anatomical structure and synaptic connections in the hippocampal CA3 region, a three-layered Hopfield-like neural network model of hippocampal CA3 was proposed and then used to simulate associative memory functions in three circumstances: normal, synaptic deletion and synaptic compensation, according to Ruppin's synaptic deletion and compensation theory. The influences of AD on hetero-associative memory were further analyzed. The simulated results showed that the established three-layered Hopfield-like neural network model of hippocampal CA3 has both auto-associative and hetero-associative memory functions. With increasing synaptic deletion level, both associative memory functions were gradually impaired and the mean firing rates of the neurons within the network model were decreased. With gradual increasing synaptic compensation, the associative memory functions of the network were improved and the mean firing rates were increased. The simulated results suggest that the Hopfield-like neural network model can effectively simulate both associative memory functions of the hippocampal CA3 region. Synaptic deletion affects both auto-associative and hetero-associative memory functions in the hippocampal CA3 region, and can also result in memory dysfunction. To some extent, synaptic compensation measures can offset two kinds of associative memory dysfunction caused by synaptic deletion in the hippocampal CA3 area. Associative memory, one of the major cognitive functions in the hippocampal CA3 region, includes auto-associative memory and hetero-associative memory. Many previous studies have shown that Alzheimer's disease (AD) can lead to loss of functional synapses in the central nervous system, and associative memory functions in patients with AD are often impaired, but few studies have addressed the effect of AD on hetero-associative memory in the hippocampal CA3 region. In this study, based on a simplified anatomical structure and synaptic connections in the hippocampal CA3 region, a three-layered Hopfield-like neural network model of hippocampal CA3 was proposed and then used to simulate associative memory functions in three circumstances: normal, synaptic deletion and synaptic compensation, according to Ruppin's synaptic deletion and compensation theory. The influences of AD on hetero-associative memory were further analyzed. The simulated results showed that the established three-layered Hopfield-like neural network model of hippocampal CA3 has both auto-associative and hetero-associative memory functions. With increasing synaptic deletion level, both associative memory functions were gradually impaired and the mean firing rates of the neurons within the network model were decreased. With gradual increasing synaptic compensation, the associative memory functions of the network were improved and the mean firing rates were increased. The simulated results suggest that the Hopfield-like neural network model can effectively simulate both associative memory functions of the hippocampal CA3 region. Synaptic deletion affects both auto-associative and hetero-associative memory functions in the hippocampal CA3 region, and can also result in memory dysfunction. To some extent, synaptic compensation measures can offset two kinds of associative memory dysfunction caused by synaptic deletion in the hippocampal CA3 area.
出处 《Neural Regeneration Research》 SCIE CAS CSCD 2010年第22期1694-1700,共7页 中国神经再生研究(英文版)
基金 the National Natural Science Foundation of China,No.30870649 the Natural Science Foundation of Tianjin,No.08JCYBJC03300
关键词 hippocampal CA3 region Hopfield-like neural network associative memory Alzheimer's disease Izhkevich neuronal model firing rate hippocampal CA3 region Hopfield-like neural network associative memory Alzheimer's disease Izhkevich neuronal model firing rate
  • 相关文献

参考文献18

  • 1Menschik ED,Finkel LH.Neuromodulatory control of hippocampal function:towards a model of Alzheimer's disease.Artif Intell Med.1998;13(1-2):99-121.
  • 2Bierman EJ,Comijs HC,Jonker C.The effect of anxiety and depression on decline of memory function in Alzheimer's disease.Int Psychogeriatr.2009;21(6):1142-1147.
  • 3Hasegawa H.An Associative Memory of hodgkin-huxley neuron networks with willshaw-type synaptic couplings.J Phys Soc Jpn.2001;70(7):2210-2219.
  • 4Perus M.Neural networks as a basis for quantum associative networks.Neural network world.2000;10(6):1001-1013.
  • 5Samura T,Hattori M,Ishizaki S.Sequence disambiguation and pattern completion by cooperation between autoassociative and heteroassociative memories of functionally divided hippocampal CA3.Neurocomputing.2008;71(16-18):3176-3183.
  • 6Savioz A,Leuba G,Vallet PG.et al.Contribution of neural network to Alzheimer disease's progression.Brain Res Bull.2009;80(4-5):309-314.
  • 7Horn D,Ruppin E,Usher M,et al.Neural-based synaptic compensation:a computational study in Alzheimer's Disease.Neural Comput.1996;8(6):1227-1243.
  • 8Rolls ET,Kesner RP.A computational theory of hipicampal function,and empirical tests of the theory.Prog Neurobiol.2006;79(1):1-78.
  • 9Hasselmo ME,McClelland JL.Neural models of memory.Curr Opin Neurobiol..1999;9(2):184-188.
  • 10Menschik ED,Finkel LH.Cholinergic neuromodulation and Alzheimer's disease:from single cells to network simulations.Prog Brain Res.1999;121:19-45.

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部