摘要
目的 总结咪达唑仑口服镇静术对口腔诊疗不配合的儿童患者的临床效果,探讨年龄因素对咪达唑仑治疗效果和安全性的影响.方法 选取109例对口腔诊疗不配合的儿童患者,在门诊环境下实施咪达唑仑口服镇静术辅助诊疗,给药剂量为0.50～0.75 mg/kg,记录各项评价指标并对≤3岁组（40例）和＞3岁组（69例）的治疗效果和安全性进行分析、比较.结果 镇静治疗总成功率为71%（77/109）,≤3岁组治疗成功率[58%（23/40）]显著低于3岁以上组[78%（54/69）]（x2=5.26,P＜0.05）;总不良反应发生率为17%（19/109）,≤3岁组不良反应发生率[28%（11/40）]显著高于3岁以上组[12%（8/69）],x2=4.24,P＜0.05.结论 咪达唑仑口服镇静术对3岁以上患者治疗效果好,不良反应相对少;口服咪达唑仑0.50～0.75 mg/kg的剂量范围安全有效.
Objective To summarize the effect of oral midazolam sedation in a group of uncooperative patients in pediatric dentistry and analyze the influence of age on treatment results and safety.Methods Oral midazolam conscious sedation （dosages range： 0. 50-0. 75 mg/kg） was applied to 109 uncooperative pediatric patients in outpatient department. The patients were divided into two age groups：group A （under 3 years） and group B （over 3 years）. Treatment results and safety were statistically analyzed. Results The mean success rate was 71% （77/109）, which was higher in group B[78%（54/69）]than in group A[58% （23/40）]. The incidence of adverse reactions was 17% （19/109）,which was higher in group A [28% （11/40）] than in group B [12% （ 8/69 ）]. Conclusions Oral midazolam conscious sedation at a dosage range of 0. 50-0. 75 mg/kg is more effective and safe in pediatric dental patients over 3 years of age.
出处
《中华口腔医学杂志》
CAS
CSCD
北大核心
2010年第12期770-772,共3页
Chinese Journal of Stomatology
基金
CMB医学研究和临床技术开发基金（A350600）
