摘要
目的探讨血浆内皮素-1(ET-1)和血管内皮生长因子(VEGF)在血管性认知功能障碍(VCI)及痴呆(VaD)发病过程中的作用。方法脑梗死143例,随访3个月,依据蒙特利尔认知评估量表(MoCA)和临床痴呆评定量表(CDR)评分将其分为无认知功能障碍(N-VCI)组、血管性认知障碍无痴呆(VCIND)组、血管性痴呆(VaD)组,用放射免疫法测定血浆ET-1水平,酶联免疫分析法测定血浆VEGF的水平,并对血浆ET-1和VEGF进行相关性分析。结果 (1)VaD组患者血浆ET-1含量明显高于VCIND组及N-VCI组,VCIND组患者血浆ET-1水平明显高于N-VCI组,差异均具统计学意义(P<0.01);VaD组患者血浆VEGF含量明显低于VCIND组及N-VCI组,VCIND组亦明显低于N-VCI组,差异均具统计学意义(P<0.01)。(2)血浆ET-1水平与VEGF存在明显负相关(r=-0.808,P<0.01)。(3)VaD组患者血浆ET-1与MoCA值成负相关(r=-0.719,P<0.01),VaD患者血浆VEGF与MoCA评分成正相关(r=0.670,P=0.01);而N-VCI、VCIND组患者血浆ET-1、VEGF与MoCA值无相关性(P>0.05)。结论高ET-1和低VEGF参与了VCI及VaD的发生发展过程,血浆ET-1与VaD病情成正相关,血浆VEGF与VaD病情成负相关,这些指标的监测可作为判断VaD病情轻重的重要依据。
Objective To investigate the role of endothelin-1 （ ET-1 ） and vascular endothelial growth factor（VEGF） in the pathogenesis of Vascular Congnitive Impairment（VCI） and vascular dementia （VaD） . Methods Follow-uped patients who were after Cerebral infarction 3 months, patients were divided into No cognitive Impairment （N-VCI） group , cognitive impairment,no dementia（CIND） group and Vascular dementia （VaD） group by Montreal Cognitive Assessment Clinical Dementia Rota scales. Radio-immunity was used to detect the concentration of ET-1 and Enzyme-linked immunosorbent assay（ELISA） was used to detect the concentration of VEGF in the plasma of the patients, then, analysed the correlation On plasma ET- 1 and VEGF. Results （ 1 ） The plasma of ET-1 in VaD group were significantly higher than that of CIND group and N-VCI group, CIND group higher than that of N-VCI group （ P 〈0.01 ）, but VEGF in VaD group were lower than that of CIND group and N-VCI group, CIND group lower than that of N-VCI group, there were significantly Statistical differences （ P 〈 0.01 ）. （ 2 ） The plasma of ET-1 showed negative correlation with VEGF（ r = -0. 808, P 〈 0.01 ）. （ 3 ） The plasma of ET-1 in VaD group showed negative correlation with MoCA scales （ r = -0. 719, P 〈 0.01 ）, but The plasma of VEGF in VaD was signifyeantly positively correlated with MoCA scales （ r = 0. 670, P = 0. 01 ）. Conclusions High ET-1 and low VEGF take part in the process of VCI and VaD, The plasma of ET-1 showed a positive correlation with VaD condition,and VEGF showed negative correlation with VaD condition, monitoring of these indicators can be used to judge the severity of VaD.
出处
《中华脑血管病杂志（电子版）》
2010年第6期9-12,共4页
Chinese Journal of Cerebrovascular Diseases(Electronic Edition)
基金
宁夏回族自治区科技攻关项目[2010]168
关键词
脑梗死
内皮素-1
血管内皮生长因子
血管性认知功能障碍
血管性痴呆
Cerebral infarction
Endothelin-1
Vascular endothelial growth factor
Vascular Congnitire impairment
Vascular dementia
