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Three-component Reaction of Aromatic Aldehyde,Malononitrile and Aliphatic Amine Leading to Different Pyridine Derivatives

Three-component Reaction of Aromatic Aldehyde,Malononitrile and Aliphatic Amine Leading to Different Pyridine Derivatives
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摘要 The three-component reaction of aromatic aldehyde,malononitrile and aliphatic amine in a mixed solvent of methanol and water exhibited very interesting molecular diversity and gave the derivatives of polysubstituted N-methyldihydropyridines,2-dialkylaminopyridines and 2-methoxypyridines as main products according to the structure of aliphatic amines used. The three-component reaction of aromatic aldehyde,malononitrile and aliphatic amine in a mixed solvent of methanol and water exhibited very interesting molecular diversity and gave the derivatives of polysubstituted N-methyldihydropyridines,2-dialkylaminopyridines and 2-methoxypyridines as main products according to the structure of aliphatic amines used.
出处 《Chemical Research in Chinese Universities》 SCIE CAS CSCD 2010年第6期937-941,共5页 高等学校化学研究(英文版)
基金 Supported by the National Natural Science Foundation of China(No.20972132)
关键词 Multicomponent reaction MALONONITRILE ALDEHYDE Dihydropyridine PYRIDINE AMINOPYRIDINE Multicomponent reaction Malononitrile Aldehyde Dihydropyridine Pyridine Aminopyridine
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