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EML4-ALK融合基因在非小细胞肺癌信号转导中的作用 被引量：4

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摘要 过去认为，染色体易位是一种常见于血液系统肿瘤的遗传学异常，这种染色体的变异往往在肿瘤的发生及分化过程发挥重要作用。染色体易位可以产生新的融合基因，或引起某些基因的启动子异常，从而使这些基因在表达水平失去调节，而过度活化的基因编码产物则使正常细胞转化为肿瘤细胞。随着研究的深入及检测手段的进步，越来越多由于染色体易位而出现的融合基因在实体瘤中检出，其在实体瘤形成中发挥的作用也越来越得到人们的重视。
作者 张一方 吴一龙
机构地区 广东省肺癌研究所广东省人民医院广东省医学科学院
出处 《癌症进展》 2010年第6期530-537,共8页 Oncology Progress
基金 国家自然科学基金资助项目(项目编号:81071699)
关键词 间变淋巴瘤激酶 融合基因 信号转导 非小细胞肺癌
分类号 R734.2 [医药卫生—肿瘤]
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参考文献50

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同被引文献51

  • 1陆舜.晚期非小细胞肺癌患者个体化治疗的新突破[J].上海交通大学学报（医学版）,2011,31(3):261-264. 被引量：4
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癌症进展
2010年 第6期

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