摘要
鼻息肉是多种致病因素作用下鼻黏膜的慢性持续性炎症,不同患者的致病因素可能不同,其病因可能与感染相关因素和变态反应因素关系最为密切。细胞因子网络在鼻息肉的形成及发生发展中起了非常重要的作用,这些细胞因子包括促炎因子、抗炎因子、趋化因子以及某些细胞因子受体等。鼻息肉中有些细胞因子的表达水平大幅度提高,主要包括白细胞介素8、肿瘤坏死因子α、嗜酸粒细胞趋化因子、白细胞介素6受体、肿瘤坏死因子受体,这些细胞因子的表达及其互相调控可能是鼻息肉发病机制的重要环节。
Nasal polyps can be defined as a chronic inflammatory disease from nasal mucosa caused by various etiological factors.Infection and allergy may be the most important factors in the pathogenesis of nasal polyps.Cytokines including inflammatory factors,anti-inflammatory factors,chemokines and their receptors maybe play important roles in the formation and development of nasal polyps.The expression of interleukin 8、tumor necrosisi factor-α,eotaxin,interleukin 6 receptor,TNF receptor and some other cytokines have been found up-regulated in nasal polyps.And they also maybe play important roles in the pathogenesis of nasal polyps.
出处
《医学综述》
2010年第23期3606-3608,共3页
Medical Recapitulate
