6Rahmouni K,Morgan DA,Morgan CM,et al.Role of selective leptinresistanceindiet-inducedobesity hypertension[J].Diabetes,2005,54:2012-2018.
7Vecchione C,Maffei A,Colella S,et al.Leptin effect on endothelial nitric oxide is mediated through Akt-endothelial nitricoxide synthase phosphorylation pathway[J].Diabetes,2002,51:168.
8Juan CC,Chuang TY,Lien CC,et al.Leptin increases endothelin type A receptor levels in vascular smooth muscle cells[J].Am K Physiol Endocrinol Metab,2008,294(3):481.
4[5]Aizawa-Abe M,Ogawa Y,Masuzaki H,et al.Pathophysiological role of leptin in obesity-related hypertension[J].J Clin Invest,2000,105:1243-1252.
5[6]Mark AL,Shaffer RA,Correia ML,et al.Contrasting blood pressure effects of obesity in leptin-deficient ob/ob mice and agouti yellow obese mice[J].J Hypertens,1999,17:1949-1953.
6[7]Minokoshi Y,Alquier T,Furukawa N,et al.AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus[J].Nature,2004,428:569-574.
7[8]Bates SH,Stearns WH,Dundon TA,et al.STAT3 signaling is required for leptin regulation of energy balance but not reproduction[J].Nature,2008,421:856-859.
8[9]Niswender KD,Schwartz MW.Insulin and leptin revisited:adiposity signals with overlapping physiological and intracellular signaling capabilities[J].Front Neuroendocrinol,2003,24:1-10.
1Koh K K, Park S M, Quon M J. Leptin and cardiovascu lar disease response to therapeutic intervention[J]. Circu lation, 2008,117 : 3238-3249.
2Craig A, Lygate, Steffen Bohl, et al. Moderate elevation of intracellular creatine by targeting the creatine trans- porter protects mice from acute myocardial infarction[J]. Cardiovascular Research, 2012,96,466-475.
3Hilzendeger A M, Morais,R L,Todiras M, et al. Leptin regulates ACE activity in mice[J]. J Mol Med, 2010,88 (9) :899-907.
4Jeffrey P, Cardinale, Srinivas Sriramula. Angiotensin Ⅱ-Induced hypertension is modulated by nuclear factor- kB in the paraventricular nucleus [J]. Hpertention, 2012,59:113-121.