摘要
目的：探讨＂质子泵抑制剂＋两种抗生素＋铋剂＂治疗幽门螺杆菌相关性胃溃疡的疗效.方法：以我院42例幽门螺杆菌阳性的胃溃疡患者为治疗组,以同期收治的40例幽门螺杆菌阳性的胃溃疡患者为对照组,治疗组给予奥美拉唑＋阿莫西林＋克拉霉素＋丽珠得乐冲剂治疗,对照组给予奥美拉唑＋阿莫西林＋克拉霉素治疗,比较2组的疗效.结果：2组痊愈率及有效率,差异没有统计学意义,P＞0.05;治疗组显效率明显高于对照组,无效率明显低于对照,差异均具有统计学意义,P＜0.05.经过治疗后,治疗组HP快速尿素酶试验转阴32例,根除率为76.19%,对照组转阴21例,根除率52.50%,治疗组根除率明显高于对照组,差异具有统计学意义,P＜0.05.结论：质子泵抑制剂＋两种抗生素＋铋剂疗法能更好杀灭HP,促进胃溃疡的愈合.
Objective：To investigate the therapy which include proton pump inhibitor,two kinds of antibiotics and bismuth for treating helicobacter pylori ralated gastric ulcer. Methods：42 cases of helicobacter pylori ralated gastric ulcer in our hospital were as the therapeutic group. 40 cases of helieo- baeter pylori ralated gastric ulcer patients were as the control group at the same time. The therapeutic group was gave omeprazole,amoxicillin,clarithromyein and franc sidel granules. The control group was gave omeprazole, amoxicillin and clarithromycin. To compare the effeacy of 2 groups. Results：To compare the rate of cure and effect in the two group. The difference was not statistically significant, P〉0.05. The rate of obvious effect in the therapeutic group was higher than the control group. The difference was statistically significant, P〈0.05. The ineffective rate in the therapeutic group was lower than the control group. The difference was statistically significant, P〈0.05. After treatment, 32 cases who was gave HP rapid urease test in the therapeu- tic group was negative. The eradication rate was 76.19 ~/~. 21 cases in the control group was negative. The eradication rate was 52.50~. The eradication rate in the therapeutic group was higher than the control group. The difference was statistically significant, P〈0.05. Conclusion：The therapy which in- elude proton pump inhibitor,two kinds of antibiotics and bismuth had better effect to kill helicobacter pylori and accelerate the healing of gastric ulcer.
关键词
胃溃疡
幽门螺杆菌
质子泵抑制剂
铋剂
抗生素
Gastric ulcer
Helicobacter pylori
Proton pump inhibitor
Bismuth
Antibiotics
