摘要
目的:探讨幼鼠早期癫痫持续状态与成鼠后海马硬化的关系;探讨表鬼臼素对海马硬化的影响。方法:采用锂-匹罗卡品腹腔注射制成幼鼠癫痫持续状态模型,应用Timm组织化学染色方法观察苔藓纤维发芽情况。结果:表鬼臼素干预组海马结构的损害与匹罗卡品对照组一致,苔藓纤维发芽现象较匹罗卡品组轻。结论:幼鼠早期长时间的痫性发作与成鼠后海马硬化有关;表鬼臼素对海马硬化的发生可能有抑制作用。
Objective: To investigate the relationship between status epilepticus ( SE) in early immature rats and hippocampal sclerosis in their mature rats,and to observe the protective effect of podophyllotoxin on hippocampal sclerosis. Methods: Rats were injected Lithium-pilocarpine intrapentoneally to establish a temporal lobe epilepsy model. Timm histochemical technique was adopted to study mossy fiber sprouting. Results: The podophyllotoxin interferential group had the same hippocampal formation damage with the Lithium-pilocarpine group,while the mossy fiber sprouting was less. Conclusion: The prolonged seizure in early immature rats was related with the hippocampal formation of mature rats,and podophyllotoxin may have protective effects to hippocampal sclerosis.
出处
《西北国防医学杂志》
CAS
2010年第6期439-441,共3页
Medical Journal of National Defending Forces in Northwest China