摘要
目的:探讨骨质疏松性椎体压缩骨折(OVCFs)经皮椎体成形术(PVP)后非手术椎体骨折的相关因素。方法:2007年1月～2010年3月门诊和病房共收治OVCFs PVP术后非手术椎体骨折患者42例,男8例,女34例,年龄55～82岁,平均67.3岁,均行脊柱X线片及MRI检查,确诊为相邻或非相邻椎体骨折;选取同期随访的PVP术后非手术椎体无骨折患者68例,男17例,女51例,年龄52～75岁,平均60.1岁。应用双能X线吸收法测定腰椎(L2～L4)骨密度值,并记录患者年龄、性别、体重指数、术前是否长期(超过1年)服用糖皮质激素类药物、手术部位(胸椎或腰椎)及单双侧入路等情况,分析引起非手术椎体骨折的相关因素。结果:单因素分析显示两组患者在年龄、骨密度及是否长期服用糖皮质激素方面比较差异有统计学意义(P<0.05),在性别、体重指数、手术部位及入路方面比较差异无统计学意义(P>0.05)。多因素分析显示高龄、骨密度T值≤-2.5SD及长期服用糖皮质激素是导致PVP术后非手术椎体骨折的危险因素,其OR值分别为3.775、5.980、3.401(P<0.05)。结论:高龄、骨质疏松及服用糖皮质激素药物超过1年是导致OVCFs患者PVP术后非手术椎体骨折的相关因素。
Objective：To investigate the correlative factors associated with non-surgical vertebral fractures after percutaneous vertebroplasty （PVP） for osteoporotic vertebral compression fraetures（OVCFs）.Method：From January 2007 to March 2010,42 out- and in-patients with non-surgical vertebral fi＇actures after PVP for OVCFs were included in this study.There were 8 males and 34 females with the average age of 67.3 years （range,55-82 years old）.All patients underwent X-Ray and MRI to confirm the onset of non-surgical segment fracture.68 patients without the non-surgical segment fracture after PVP were selected as the control, who were 17 males and 51 females with an average age of 60.1 years （range,52-75 years old）.The bone mineral density（BMD） of lumbar spine was measured by dual-energy X-ray absorptiometry,and the patients＇ age, sex,body mass index （BMI）,operative site and approach,administration of glncocoriicoids for more than 1 year or without were recorded.The correlative factors associated with the non-surgical vertebral fractures were analyzed.Result：Univariate analysis showed statistically significant differences（P〈0.05 ） between two groups with respect to age,BMD,whether to take glucocorticoids,whereas no significant differences（P〉0.05） with regard to sex,BMI,operative site and approach.Multiple logistic regression analysis showed old age,BMD ≤-2.SSD,ad- ministration of glueocorticoids for more than 1 year were the predominant risk factors associated with non-surgical segment fracture,with the OR value of 3.775,5.980 and 3.401 respectively （P〈0.05）.Conclusion：Old age,osteoporosis and administration glucocorticoids for more than 1 year are the relative risk factors of nonsurgical vertebral fractures after PVP for OVCFs.
出处
《中国脊柱脊髓杂志》
CAS
CSCD
北大核心
2010年第12期975-979,共5页
Chinese Journal of Spine and Spinal Cord
关键词
骨质疏松性椎体压缩骨折
经皮椎体成形术
非手术椎体骨折
相关因素
Osteoporotic vertebral compression fractures
Percutaneous vertebroplasty
Non-surgieal vertebral fractures
Correlative factors
