摘要
目的观察清胰化积中药联合动脉灌注化疗(TAC)及胰腺肿瘤放疗治疗手术无法切除的局部晚期或转移性胰腺癌的疗效及不良反应。方法共80例胰腺癌患者纳入本研究,在接受TAC(吉西他滨+顺铂或奥沙利铂)及胰腺肿瘤放疗(36～40Gy/1.8～2Gy)的基础上,随机分为中药组41例和对照组39例,中药组给予清胰化积中药,连服8周。比较两组间的客观疗效、生存情况及不良反应等。结果中药组中位生存期5.1个月,对照组4.2个月,一年生存率两组分别为9.8%和5.1%(P<0.05)。中药组部分缓解(PR)13.9%,稳定(SD)33.3%,进展(PD)52.8%;对照组PR0,SD36.1%,PD63.9%,组间比较无统计学意义。治疗相关不良反应两组间差异无统计学意义。结论清胰化积中药联合TAC及放疗可延长晚期胰腺癌患者生存期。
Objective To observe the effect of Qingyi Huaji（clearing pancreas and dissolving stasis）herbal decoction combined with transcatheter arterial chemotherapy（TAC）and radiotherapy in the treatment of advanced or metastatic pancreatic cancer.Methods Totally 80 pancreatic cancer patients received TAC（gemcitabine and cisplatin or oxaliplatin）and radiotherapy 36～40 Gy/1.8～2.0 Gy and they were randomized into herbal group（41 cases）and control group（39 cases）.The herbal group was administered Qingyi Huaji herbal decoction,8 weeks in succession.Objective effect,survival,and treatment-related adverse reaction of the two groups were compared.Results In the herbal group the median survival time was 5.1 months and was 4.2 months in the control group,and one-year survival rate was 9.8% and 5.1% respectively in two groups（P0.05）.PR,SD and PD of the herbal group was 13.9%,33.3% and 52.8% respectively,while PR,SD and PD of the control group was no significant difference between groups.The treatment-related adverse reaction of the two groups was without significant difference.Conclusion Qingyi Huaji herbal decoction in combination with TAC may prolong the survival time of patients with advanced pancreatic cancer.
出处
《中医杂志》
CSCD
北大核心
2010年第12期1093-1096,1100,共5页
Journal of Traditional Chinese Medicine
基金
上海市科技发展基金资助项目(02DZ19106)
关键词
胰腺癌
动脉灌注化疗
放疗
清胰化积
生存期
Pancreatic cancer
Transcatheter arterial chemotherapy
Radiotherapy
Qingyi Huaji（clearing pancreas and dissolving stasis）
Survival
