Design,synthesis and anti-proliferative studies of a novel series of indirubin derivatives 被引量：1

Design,synthesis and anti-proliferative studies of a novel series of indirubin derivatives

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摘要 A series of novel derivatives of indirubin were synthesized and evaluated for their anti-proliferative activity against human cancer cell lines of SGC7901,A549,HL-60,SK-BR-3 and HCT116.Most of the compounds displayed more potent activity than Sunitinib.In addition,the derivatives showed improved water solubility,which may be favorable to their pharmacokinetic performances.

作者 Tian Cai Wang Ju Zhi Wei Chuan Sheng Guo Hui Bin Zhang Hou Xing Fan

机构地区 Center of Drug Discovery Shanghai Sun-sail Pharmaceutical Science & Technology Co.

出处《Chinese Chemical Letters》 SCIE CAS CSCD 2010年第12期1407-1410,共4页 中国化学快报（英文版）

关键词 Anti-proliferative activity INDIRUBIN SUNITINIB Anti-proliferative activity Indirubin Sunitinib

分类号 TQ461 [化学工程—制药化工] Q-4 [生物学]

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参考文献14

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Chinese Chemical Letters

2010年第12期

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Design,synthesis and anti-proliferative studies of a novel series of indirubin derivatives 被引量：1

参考文献14

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二级引证文献5

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