摘要
目的观察来氟米特联合中小剂量激素治疗进展性IgA肾病的疗效和安全性。方法将确诊为IgA肾病的60例患者随机分为2组:观察组给予来氟米特联合泼尼松治疗,对照组仅予泼尼松治疗。观察2组治疗前和治疗后1,3,6个月的相关临床指标变化情况,同时记录不良反应。结果治疗1,3,6个月后,2组24 h尿蛋白定量、血肌酐均有下降(P均<0.01),血清白蛋白均有升高(P均<0.01),肾小球滤过率也有所上升(P均<0.01)。观察组在临床指标方面改善的幅度要优于对照组(P均<0.01)。观察组完全缓解率、总有效率明显高于对照组(P均<0.05)。观察组不良反应较轻,患者耐受性良好。结论来氟米特联合中小剂量激素治疗进展性IgA肾病,近期降尿蛋白疗效显著,且安全,患者有较好的耐受性。
Objective It is to observe the effects and safety of leflunomide combined with glucocorticoid in the treatment of progressive IgA nephropathy.Methods 60 patients with biopsy-confirmed IgA nephropathy were randomly divided into two groups.The observation group was given leflunomide combined with glucocorticoid,and control group was only given glucocorticoid.The changes of correlated clinical datas were observed and recorded before treatment and in the 1st,3rd,and 6th month after treatment,as well as adverse events were recorded.Results After one,three and six months＇ treatment,the proteinuria decreased significantly（P0.01）,serum albumin increased significantly（P0.01）,and glomerular filtration rate roze up in both groups.But the improving degree of clinical indexes in observation group was better than than in control group（P0.01）.The complete remission rate and total efficient rate in observation group were higher than that in control group（P0.05）.The patients in observation group had less adverse events and better tolerance.Conclusion The treatment with Leflunomide combined with low or mild dosage of glucocorticoid for progressive IgA nephropathy has a significant effect on proteinuria with a good safety and tolerance.
出处
《现代中西医结合杂志》
CAS
2011年第1期13-15,共3页
Modern Journal of Integrated Traditional Chinese and Western Medicine
