摘要
目的分析古籍文献中治疗变应性鼻炎(AR)的处方用药及配伍规律,为临床治疗AR提供参考。方法筛选古代医籍文献中治疗AR的方剂,进行信息标准化处理,应用数据挖掘技术中的频数与频繁项集及关联规则对筛选的方剂进行分析。结果共筛选了101个经典处方,组成药味数在10味以下的方剂占总方剂数75.25%。方中以味辛质轻气薄之品的出现频数最高,其中细辛出现频数42次,占总处方数的41.5%;方中出现频率最高的药对为细辛、白芷,频数22次;出现频率最高的三味中药集合为川芎、白芷、细辛,频数11次;出现频率最高的四味中药集合为当归、白芷、川芎与细辛,频数7次。关联分析结果显示,在治疗AR的方剂中紫苏常配甘草,附子常配细辛,白芷、细辛常配川芎,羌活、防风常配白芷。结论古代医籍文献中治疗AR的处方药味不多而用药精当,内外兼顾,标本兼治,能为中医药临床治疗AR提供一定的借鉴与参考。
Objective To analyze the compatibility law of the herbs used in ancient prescriptions treating allergic rhinitis （AR） to provide reference for its clinical treatment today. Methods The ancient classical prescriptions treating AR were enrolled and processed with information standardization. Data mining method （frequent itemsets and association rules） was used to analyze the compatibility law of the herbs. Results Totally 101 prescriptions were studied. The result showed that those with less than 10 herbs occupied 75.25 % of the total prescriptions. The herbs pungent in flavour, light in weight, and mild in smell were used in the highest frequency, of which, Xixin （Herba asari） appeared 42 times, being 41.5% of the total prescriptions. Xixin （Herba asari） and Baizhi （Radix angelicae） as a pair of herbs appeared 22 times, being the highest in frequency. Chuangx long （Rhizoma chuanxiong）, Baizhi （RadD： angelieae）, and Xixin （Herba asari） as a 3 itemset appeared 11 times, being the highest in frequency. Danggui （Angelica sinensis）, Baizhi （Radix angelicae）, Chuangxiong （Rhizoma chuanxiong）, and Xixin （Herba asari） as a 4 itemset appeared 7 times, being the highest in frequency. The analysis on association rule showed that Zisu （Purple perilla） was commonly coupled with Gancao （Radix glycyrrhizae）, Fuzi （Radix aconiti carmiehaeli） with Xixin （Herba asari）, Baizhi （Radix angelicae） and Xixin （Herba asari） with Chuangxiong （Rhizorna chuanxiong）, and Qianghuo （Rhizoma seu radix notopterygii） and Fangfeng （Radix ledebouriellae） with Baizhi （Radix angelicae）. Conclusion The herbs in ancient prescriptions for AR were not many but exact in effect in treating interior and exterior and acting comprehensively on symptoms and root cause, providing a reference for its treatment nowadays.
出处
《中医杂志》
CSCD
北大核心
2011年第1期57-59,共3页
Journal of Traditional Chinese Medicine
关键词
变应性鼻炎
方剂
配伍规律
数据挖掘
allergic rhinitis
prescriptions
compatibility
data mining
