摘要
目的分析我院7879例唐氏综合征产前筛查指标AFP和Free-β-hCG的MoM值分布情况以及总筛查阳性率情况。方法运用EXCEL软件对唐氏综合征产前筛查指标AFP和Free-β-hCG的MoM值分布情况进行描述统计,唐氏综合征总筛查阳性率采取AFPMoM值小于或者等于0.4(综合风险属低风险)和Free-β-hCGMoM值大于或者等于2.5(综合风险属低风险)的病例加综合风险阳性病例。结果两指标的MoM值均服从正偏态分布,对MoM值取对数时,指标Free-β-hCG服从正态分布,AFP仍不服从正态分布,虽然其分布正态性有所改善。AFPMoM值小于或者等于0.4的病例占总筛查例数的1.68%,Free-β-hCGMoM值大于或者等于2.5的病例占总筛查例数的3.21%,唐氏综合征总筛查阳性率为11.22%。结论我院7879例唐氏综合征产前筛查指标AFP和Free-β-hCG的MoM值分布均服从正偏态分布,对MoM值取对数时,Free-β-hCG服从正态分布,AFPMoM值分布正态性有所改善,但仍然不服从正态分布。唐氏综合征总筛查阳性率为11.22%。
Objective： To analyze the distribution of MoM values of AFP and Free-β-hCG of 7879 pregnant women who had undergone the second trimester Downs syndrome screening program,and the overall screening positive rate.Methods： The distribution of MoM values of AFP and Free-β-hCG of 7879 pregnant women who had undergone the second trimester Downs syndrome screening program was analyzed by EXCEL,and the overall screening positive rate was calculated as the screening positive rate plus the rate that screening result was negative except AFP MOM value was less than or equal 0.4,and the rate that screening result was negative except Free-β-hCG MOM value was more than or equal 2.5.Results： Neither the AFP MoM nor the Free-β-hCG MoM was of normal distribution.The logMoM distribution of Free-β-hCG was normal while that of AFP was not,though the normality of the latter was improved That screening result was negative except AFP MOM value was less than or equal 0.4 account for 1.68%,while that screening result was negative except Free-β-hCG MOM value was more than or equal 2.5 account for 3.21%,the overall screening positive rate was 11.22%.Conclusion： Neither the AFP MoM nor the Free-β-hCG MoM was of normal distribution.The logMoM distribution of Free-β-hCG was normal while that of AFP was not,though the normality of the latter was improved.The overall screening positive rate was 11.22%.
出处
《中国优生与遗传杂志》
2010年第12期44-45,43,共3页
Chinese Journal of Birth Health & Heredity
基金
四川省卫生厅2009年立项课题中研究内容的一部分
项目编号090101
