摘要
目的研究动脉粥样硬化性脑梗死（ＡＣＩ）患者血脂水平与载脂蛋白Ｂ（ＡｐｏＢ）基因多态性及性别之间的相关性。方法运用聚合酶链反应－限制性片段长度多态性（ＰＣＲ－ＲＦＬＰ）对８６例ＡＣＩ患者和５５例正常对照（ＮＣ）进行ＡｐｏＢ的基因分析。结果①两组间等位基因频率分布无差异（Ｐ＞０．０５）；②两组间存在总胆固醇（ＴＣ）、甘油三酯（ＴＧ）、低密度脂蛋白（ＬＤＬ）、载脂蛋白Ａ（ＡｐｏＡ）、载脂蛋白Ｂ（ＡｐｏＢ）、脂蛋白（ａ）［Ｌｐ（ａ）］水平的差异（Ｐ＜０．０５）；③ＡＣＩ组血脂水平异常与性别有关（Ｐ＜０．０５）。结论ＡｐｏＢ基因多态性对ＡＣＩ患者血脂水平无明显影响；性别对脂质代谢有一定影响。
Objective\ To study the relationship between plasma lipid ApoB gene polymorphisms and sex hormones to lipoprotein levels in patients with atherosclerotic cerebral infarction (ACI). Methods\ Polymorphic sites of apolipoprotein B gene was examined by the technique of PCR RFLP in samples of 86 cases with ACI and 55 normal control subjects. Results\ ①The frequencies of X + allele had no difference between the two groups. ②The ACI group had significantly higher TC TG LDL ApoB Lp(a) and lower ApoA level, sex hormones was associated with the variation. Conclusion\ The results indicated that sex but not ApoB gene polymorphisms, influence lipid and lipoprotein metabolism.
出处
《南京医科大学学报（自然科学版）》
CAS
CSCD
1999年第4期265-267,共3页
Journal of Nanjing Medical University(Natural Sciences)
关键词
脑梗死
载脂蛋白B
基因多态性
性别
sex hormones
apolipoprotein B gene
atherosclerotic cerebral infarcion
