摘要
采用ＥＬＩＳＡ、ＩＦＡ检测特异性抗体，ＭＣＰＥＮＴ检测中和抗体和ＨＩ，进行血清学分型。结果：选择姬鼠型疫区，接种沙鼠肾细胞Ⅰ型灭活出血热疫苗安全性较好。免疫后４２天ＨＦＲＳ．Ｖ．ＩｇＧ抗体阳性率为９６４３％，ＧＭＴ＝３５１８，１８０天有明显下降，加强免疫两周后阳性率达１００％，而且１２００天仍有３６３６％人群存在１∶１０（＋）抗体；ＭＣＰＥＮＴ抗体较ＩＦＡ抗体阳性率低，但疫苗免疫人群具有特异性回忆反应。中期流行病学防病效果接种组发病率为２３５／１０万，对照组为４２９３／１０万，保护率９４５３％。
The purpose was to observe the safety,immunity,middle term epidemiological efficacy of TypeⅠ Inactivated Vaccines against HFRS prepared from tissue of Monqolian gerbils kidney.ELISA,IFA were used in testing specific antibody in sera.MCPENT was used in testing neutralization antibody.HI was used in assaying serological type.It was proved safe that the population who lived in the wild rodent epidemic area were inoculated vaccines.The seroconversion rate of HFRS.V.IgG antibody was 96 43%,GMT=35.18(42 days after primary immunization).The former dropped apparently on 180th day.The rate of seroconversion was 100%(two weeks after reinforced immunization).The 36.36% of them were still tested HFRS.V.IgG antibody(1∶10) on 1200th day.The seroconversion rate of specific antibody by MCPENT was less than by IFA.The specific reminiscence reaction was existed among the immunizated population.The epidemioloigcal effect of middle term.The incidence rate of inoculation group was 2.35/100 000 and that of the control group was 42.93/100,000.The protection rate of the vaccine was 94.53%.The result was showed safe that the population of epidemic area were inoculated the Type Ⅰ vaccine gainst HFRS.The epidemiological effect of middle term was satisfied.
出处
《中国公共卫生》
CAS
CSCD
北大核心
1999年第7期594-596,共3页
Chinese Journal of Public Health
关键词
肾综合征出血热
灭活疫苗
免疫效果
疫苗
HFRS Type Ⅰ Inactivated Vaccine Immunlogical effect Epidemiology effect
