摘要
目的:探讨预注罗库溴铵对顺式阿曲库铵快速诱导期肌松效应的影响。方法:选择开腹手术的患者80例,随机均分为4组:Ⅰ组预注氯化钠注射液3mL;Ⅱ、Ⅲ、Ⅳ组分别预注罗库溴铵0.03、0.06、0.09mg·kg-1。各组间隔3min后,使用顺式阿曲库铵快速诱导,当T1抑制100%时行气管插管。分别记录血流动力学参数、起效时间、插管条件及恢复时相指标。结果:与Ⅰ组比较,Ⅱ、Ⅲ、Ⅳ组血流动力学参数变化无显著性差异(P>0.05);Ⅱ、Ⅲ、Ⅳ组均可将顺式阿曲库铵起效时间缩短(P<0.01),其中Ⅳ组最为明显,为(136.5±22.3)s;4组患者恢复时相指标的差异无统计学意义(P>0.05),其值分别为T539.1～59.9min、T2543.0～63.5min。结论:预注罗库溴铵可缩短顺式阿曲库铵起效时间,且不影响顺式阿曲库铵恢复时相。
OBJECTIVE：To observe the effect of the pre-injection of rocuronium on rapid neuromuscular blocking induced by cis-atracurium.METHODS：80 patients underwent abdominal surgery were collected and randomly divided into 4 groups：group Ⅰ was given pre-injection of normal saline 3 mL;group Ⅱ,group Ⅲ and group Ⅳ were given pre-injection of rocuronium with dose of 0.03,0.06,0.09 mg·kg-1 respectively.In 4 groups,neuromuscular blocking was induced rapidly by cis-atracurium 3 minutes later.When T1 of 100% was inhibited,endotracheal intubation should be conducted.The change of hemodynamics,onset time,intubation conditions and T5,T25 were recorded.RESULTS：Compared with group Ⅰ,hemodynamics parameters of group Ⅱ,group Ⅲ and group Ⅳ had no obvious change（P0.05）;the onset time of cis-atracurium could be shortened（P0.01）,especially in group Ⅳ with onset time of（136.5±22.3） s.The difference of T5,T25 among 4 groups were not significant（P0.05）,and T5 and T25 were 39.1-59.9 min and 43.0-63.5 min respectively.CONCLUSION：Pre-injection of rocuronium can significantly reduce the onset time of cis-atracurium and dosen＇t affect recovery phase.
出处
《中国药房》
CAS
CSCD
北大核心
2010年第48期4529-4531,共3页
China Pharmacy
基金
四川省卫生厅科研基金资助项目(080350)
