摘要
目的：分析小牛胸腺肽（ＴＰ）改善氢化可的松（ＨＣ）抑制骨髓造血功能的作用。方法：小鼠肌肉注射ＨＣ０．５ｍｇ／ｄ２周，并用Ｈｅｐ２细胞致敏。ＴＰ组腹腔注射ＴＰ１０μｇ／ｄ，ＨＣ组腹腔注射ＮＳ０．１ｍｌ，共６ｄ。测ＲＢＣ、ＷＢＣ值，取右胫骨观察骨髓造血组织结构改变。结果：ＨＣ致骨髓明显萎缩。致敏后ＴＰ能促骨髓造血幼稚细胞和中性粒细胞增生。
Objective:To analyse the improving effect of thymic peptides(TP) on hemopoietic function of bone marrow inhibited by hydrocortisone(HC).Methods:Mice injected HC 0.5 mg/d intramuscularly for two weeks and sensitized with Hep 2 cells were divided into two groups:mice of TP group were injected with TP 10 μg/d and mice of HC group with NS 0.1 ml intrapertoneally for 6 days.RBC and WBC counts of blood and hemopoietic tissue of bone marrow of right shin bone were taken for examination.Results:HC led to distinct atrophy of bone marrow.TP can promote proliferation of hemopoietic blast cell and granulocytes after sensitization.Conclusions:TP can ameliorate the effect caused by HC on bone marrow of mice after being sensitized.
出处
《蚌埠医学院学报》
CAS
1999年第2期73-74,F002,共3页
Journal of Bengbu Medical College
