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肺癌血清肿瘤标志物meta分析 被引量:48

meta-analysis of Serum Tumor Markers in Lung Cancer
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摘要 背景与目的血清肿瘤标志物的检测对肺癌的早期诊断有着重要的意义。本研究旨在通过回顾性统计分析,总结肺癌血清肿瘤标志物检测的临床意义及特点。方法应用meta分析方法对有关肺癌血清肿瘤标志物的文献进行综合定量评价。入选712篇文献,病例组、对照组病例均>20例,共统计肿瘤血清52832例,对照血清32037例。结果 13项肿瘤标志物对肺癌具有诊断意义,CEA、CA125、CYFRA21-1、TPA、SCCAg、DKK1、NSE和ProGRP的敏感度分别为47.50%、50.11%、57.00%、50.93%、49.00%、69.50%、39.73%和51.48%,特异度分别为92.34%、80.19%、90.16%、88.41%、91.07%、92.20%、89.11%和94.89%。多指标联合分析显示,NSE+ProGRP对小细胞肺癌的诊断敏感度和特异度分别为88.90%和72.82%。SCCAg+CYFRA21-1联合肿瘤生长因子TSGF对鳞癌诊断的敏感度和特异度分别为95.30%和74.20%;CA153+Ferrtin+CEA对肺癌诊断的敏感度和特异度分别为91.90%和44.00%。结论肿瘤血清标志物对早期肺癌的诊断有临床意义,单项指标检测敏感度及特异度较低,多指标联合检测能提高诊断的敏感度和特异度。 Background and objective The detection of serum tumor markers is of great value for early diagnosis of lung cancer. The aim of this study is to summarize the clinic significance characteristics of serum markers contributing to the detection of lung cancer. Methods References about serum markers of lung cancer were estimated using meta-analysis method. 712 references which included more than 20 cases,20 controls,the serum markers of 52 832 patients with malignancies and 32 037 patients as controls were evaluated. Results Overall the detection of 13 markers play a significant part in lung cancer diagnosis. The sensitivity of CEA,CA125,CYFRA21-1,TPA,SCCAg,DKK1,NSE,ProGRP in the patients’ serum with lung cancer were 47.50%,50.11%,57.00%,50.93%,49.00%,69.50%,39.73%,51.48% and the specificity were 92.34%,80.19%,90.16%,88.41%,91.07%,92.20%,89.11%,94.89%. In the combined analysis of tumor markers: the sensitivity,specificity of NSE+ProGRP were 88.90% and 72.82% in diagnosis of small cell lung cancer,respectively. In diagnosis of squamous corcinoma,the sensitivity and specificity of TSGF+SCCAg+CYFRA21-1 were 95.30% and 74.20%. The the sensitivity and specificity of CA153+Ferrtin+CEA were 91.90% and 44.00% in diagnosis of lung cancer. Conclusion Although the assay of tumor markers in serum is useful for diagnosis of early lung cancer,the sensitivity and specificity are low. Combined detection of these tumor markers could increase sensitivity and specificity.
出处 《中国肺癌杂志》 CAS 2010年第12期1136-1140,共5页 Chinese Journal of Lung Cancer
关键词 肺肿瘤 META分析 肿瘤标记物 Lung neoplasms meta-analysis Tumor markers
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参考文献15

  • 1Parkin DM, Bray F, FerlayJ, et al. Global cancer statistics, 2002. CA Cancer J Clin, 2005, 55(2): 74-108.
  • 2余章斌,韩树萍,郭锡熔.孕早期胎儿颈项透明层在产前超声筛查胎儿畸形中价值的Meta分析[J].中国循证儿科杂志,2008,3(6):407-418. 被引量:11
  • 3Zamora J, Abraira V, Muriel A, et al. Meta-DiSc: a software for meta-analysis of test accuracy data. BMC Med Res Methodol, 2006, 6: 31.
  • 4Kawachi R, Nakazato Y, Takei H, et al. Clinical significance of preoperative carcinoembryonic antigen level for clinical stage I non-small cell lung cancer: can preoperative carcinoembr-yonic antigen level predict pathological stage? Interact Cardiovasc Thorac Surg, 2009, 9(2): 199-202.
  • 5Hatzakis KD, Froudarakis ME, Bouros D, et al. Prognostic value of serum tumor markers in patients with lung cancer. Respiration, 2002, 69(1): 25-29.
  • 6Emin Erbaycu A, Gunduz A, Batum O, et al. Pre-treatment and treatmentinduced neuron-specific enolase in patients with small-cell lung cancer: an open prospective study. Arch Bronconeumol, 2010, 46(7): 364-369.
  • 7Zateska M, Szturmowicz M, Zych J, et al. Elevated serum NSE level in locally advanced and metastatic NSCLC predispose to better response to chemotherapy but worse survival. Pneumonol Alergol Pol, 2010, 78 (1): 14-20.
  • 8Holdenrieder S, von Pawel J, Dankelmann E, et al. Nucleosomes, ProGRP, NSE, CYFRA 21-1, and CEA in monitoring first-Line chemotherapy of small cell lung cancer. Clin Cancer Res, 2008, 14(23): 7813-7821.
  • 9Racil H, Saad S, Rouhou SC, et al. The value of tumor markers in pulmonary tuberculosis. Tunis Med, 2009, 87(5): 330-333.
  • 10Sheng SL, Huang G, Yu B, et al. Clinical significance and prognostic value of serum dickkopf-1 concentrations in patients with lung cancer. Clin Chem, 2009, 55(9): 1656-1664.

二级参考文献21

  • 1宋鉴清,吴广平,赵敏,王丽,孙明喜,张丽霞.胸腔积液中CYFRA21-1、NSE的检测对肺癌的诊断意义[J].中国肺癌杂志,2005,8(3):226-226. 被引量:15
  • 2任爱国.美国一基金会发布全球出生缺陷报告[J].中国生育健康杂志,2006,17(2):121-122. 被引量:52
  • 3Bonner JA, Sloan JA, Rowland KM Jr, et al. Significance of neuron-specific enolase levels before and during therapy for small cell lung cancer. Clin Cancer Res,2000,6(2) : 597-601.
  • 4Fizazi K, Cojean I, Pignon JP, et al. Normal serum neuron specific enolase (NSE) value after the first cycle of chemotherapy: an early predictor of complete response and survival in patients with small cell lung carcinoma. Cancer, 1998,82(6) : 1049-1055.
  • 5Pujol JL, Boher JM, Grenier J, et al. Cyfra 21-1, neuron specific enolase and prognosis of non-small cell lung cancer: prospective study in 621 patients. Lung Cancer,2001,31(2-3) : 221-231.
  • 6Plebani M, Basso D, Navaglia F, et al. Clinical evaluation of seven tumour markers in lung cancer diagnosis: can any combination improve the results? Br J Cancer, 1995,72(1) : 170-173.
  • 7Ferrer J, Villarino MA, Encabo G, et al. Diagnostic utility of CYFRA 21-1, carcinoembryonic antigen, CA 125, neuron specific enolase, and squamous cell antigen level determinations in the serum and pleural fluid of patients with pleural effusions. Cancer,1999,86(8):1488-1495.
  • 8Shibayama T, Ueoka H, Nishii K, et al. Complementary roles of pro-gastrin-releasing peptide (ProGRP) and neuron specific enolase (NSE) in diagnosis and prognosis of small-cell lung cancer(SCLC). Lung Cancer,2001,32(1) : 61-69.
  • 9Stieber P, Dienemann H, Schalhorn A, et al. Pro-gastrin-releasing peptide (ProGRP)-a useful marker in small cell lung carcinomas. Anticancer Res, 1999,19(4A) : 2673-2678.
  • 10Goto K, Kodama T, Hojo F, et al. Clinicopathologic characteristics of patients with nonsmall cell lung carcinoma with elevated serum progastrin-releasing peptide levels. Cancer, 1998, 82 (6):1056-1061.

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