摘要
目的探讨血清肝细胞生长因子（HGF）及转化生长因子-β（TGF-β）水平在非小细胞肺癌患者术前分期中的意义。方法 2006年9月至2007年11月,北京朝阳医院收治临床资料完整、经病理证实的非小细胞肺癌患者50例,男30例,女20例;年龄36-76岁（62.4±10.0岁）;腺癌26例,鳞癌23例,大细胞癌1例;另选取20例正常健康人作为对照,男11例,女9例;年龄18-67岁（43.8±14.2岁）。采用酶联免疫吸附试验（ELISA）方法测定外周血清中的HGF和TGF-β水平,并分析其与非小细胞肺癌患者临床分期的关系。结果肺癌患者术前血清中HGF和TGF-β水平与患者的年龄、性别、吸烟史和组织学类型无关。T2和T3期中HGF水平高于正常对照（373.90±234.00 pg/ml vs.211.30±154.60 pg/ml,t=2.759,P=0.008;563.80±316.10 pg/ml vs.211.30±154.60 pg/ml,t=4.076,P=0.000）。肺癌T3期患者TGF-β水平高于正常对照（3.34±2.80 ng/ml vs.1.82±0.90 ng/ml,t=2.190,P=0.037）。有淋巴结转移的肺癌患者TGF-β水平高于无淋巴结转移患者（2.60±2.00 ng/ml vs.1.53±0.74 ng/ml,t=-2.387,P=0.021）。有远处转移的患者（Ⅳ期）TGF-β水平（5.97±2.65 ng/ml）显著高于其他分期。结论 HGF和TGF-β水平与肺癌的分期有关,联合术前相关检查能更准确地对疾病进行术前分期,从而制定最佳的治疗方案。
Objective To explore the significance of peripheral serum hepatocyte growth factor（HGF） and transforming growth factor-β（TGF-β） in preoperative staging of patients with non-small cell lung cancer.Methods Fifty patients,including 30 males and 20 females,with complete clinical data and final pathological diagnosis of non-small cell lung cancer were treated in Beijing Chaoyang Hospital from September 2006 to November 2007.Their age ranged from 36 to 76 years old（62.4±10.0 years old）.Among the patients,there were 26 patients of adenocarcinoma,23 patients of squamous cell carcinoma and one patient of large cell carcinoma.Twenty other normal subjects were chosen to form normal control,including 11 males and 9 females,aged from 18 to 67 years old（43.8±14.2 years old）.Peripheral serum HGF and TGF-β were measured with enzyme-linked immunosorbent assay（ELISA）,and the relationship between the level of HGF,TGF-β and preoperative staging was analyzed.Results The peripheral serum HGF and TGF-β level has no relation with patient＇s age,sex,smoking history or histology type.The level of HGF in the T2 and T3 patients was significantly higher than that of normal control（373.90±234.00 pg/ml vs.211.30±154.60 pg/ml,t=2.759,P=0.008;563.80±316.10 pg/ml vs.211.30±154.60 pg/ml,t=4.076,P=0.000）.The level of TGF-β in the T3 patients was significantly higher than that of normal control（3.34±2.80 ng/ml vs.1.82±0.90 ng/ml,t=2.190,P=0.037）.The level of TGF-β in the N1-2 patients was significantly higher than that of the N0 patients（2.60±2.00 ng/ml vs.1.53±0.74 ng/ml,t=-2.387,P=0.021）.TGF-β level（5.97±2.65 ng/ml） in patients with distant metastasis（stage Ⅳ） was significantly higher than that of patients in other stages.Conclusion The HGF and TGF-β level is related to the staging of lung cancer.Such examinations combined before operation may present a reference value for preoperative staging and providing the best treatment plan for the patients.
出处
《中国胸心血管外科临床杂志》
CAS
2010年第6期462-466,共5页
Chinese Journal of Clinical Thoracic and Cardiovascular Surgery
关键词
肝细胞生长因子
转化生长因子-Β
肺癌分期
治疗
Hepatocyte growth factor
Transforming growth factor-β
Stage of lung cancer
Treatment
