摘要
目的 探讨甲状腺良恶性病变组织中S100A4蛋白的表达及其临床意义.方法 应用微波-LSAB免疫组化法检测50例甲状腺癌、45例甲状腺腺瘤和20例癌旁甲状腺组织中S100A4蛋白的表达.结果 S100A4蛋白表达阳性率在甲状腺癌组织中（78.0%）显著高于甲状腺腺瘤（15.6%）和癌旁甲状腺组织（全部阴性）（P＜0.01）.S100A4蛋白表达阳性率与甲状腺癌组织类型无关;有淋巴结转移者显著高于无淋巴结转移者（P＜0.05）;临床分期Ⅲ～Ⅳ期病例显著高于Ⅰ～Ⅱ期病例（P＜0.05）.S100A4蛋白阳性的甲状腺癌复发及病死率显著高于阴性者（P＜0.05）.结论 检测S100A4蛋白表达,有助于鉴别甲状腺良、恶性病变,作为一种预测甲状腺癌转移的分子标志物,对评估患者预后具有一定临床价值.
Objective To investigate the expression of S100A4 protein in benign and malignant thyroid tissues and its clinical significance. Methods Expression of S100A4 protein in thyroid cancers （50 cases）, adenoma （45 cases） and adjacent noncancerous tissue （20 cases） was respectively studied by microwave-LSAB immunohistochemical staining. Results The positive rate of S100A4 protein in thyroid cancer and adenoma was 78.0% and 15.6% respectively. No S100A4 protein expression was found in any adjacent noncancerous tissue （P 〈0. 01）. No correlation was observed between expression of S100A4 protein and histological grading of thyroid cancer. Expression of S100A4 protein in lymph node metastasis and staging Ⅲ-Ⅳ was both higher than that in negative cases and staging Ⅰ -Ⅱ （P 〈0. 05）. The rate of recurrence and death in S100A4 protein positive cases were notably higher than that in negative cases （P 〈 0. 05）. Conclusions S100A4 protein expression can help to distinguish benign and malignant thyroid tissues. It can be used as a molecular marker to predict thyroid metastasis.
出处
《中华内分泌外科杂志》
CAS
2010年第6期375-378,共4页
Chinese Journal of Endocrine Surgery
