摘要
目的探讨血清VEGF和MMP-9水平与急性白血病(AL)的相关性。方法采用双抗体夹心酶联免疫吸附法(ELISA法)检测65例不同时期、不同类型的急性白血病患者和20例正常对照组患者血清中VEGF和MMP-9的水平。结果初治组和复发组的血清VEGF和MMP-9水平明显高于正常对照组和缓解组,有髓外浸润组明显高于无髓外浸润组,差异有显著性(均P<0.01);缓解组高于正常对照组,初治组高于复发组,但差异无显著性(均P>0.05);VEGF和MMP-9水平呈正相关(P=0.615,P<0.01)。结论 AL患者血清VEGF和MMP-9水平存在异常并与病情密切相关,显著增高者易发生髓外浸润,两者共同参与急性白血病的发生、发展并具有协同作用。
【Objective】 To study the correlation between acute lekemia and the level of VEGF and MMP-9 in serum.【Methods】 To determine the level of VEGF and MMP-9 in serum for 65 patients with different period and different type of acute lekemia （AL） and 20 cases of control group.【Results】 The levels of VEGF and MMP-9 in serum in initial treatment group and recrudescent group are all higher than those in control group and remittent group,and so as extramedullary infiltration more than nonextramedullary infiltration,there is statistical significant difference （P 0.05）;Remittent group is higher than control group,so as initial treatment group than recrudescent group,but there is no statistical significant difference （P 0.05）.There is positive correlation between the level of VEGF and MMP-9 （r =0.615,P 0.01）.【Conclusion】 VEGF and MMP-9 in serum of patients with AL are abnormal and closely correlation with the illness,it is easy to get extramedullary infiltration if they increase significantly.They take part in the nosogenesis of AL and have synergistic reaction with each other.
出处
《中国现代医学杂志》
CAS
CSCD
北大核心
2010年第22期3426-3428,共3页
China Journal of Modern Medicine
