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LOW MOLECULAR WEIGHT HEPARIN DECREASES THE ALBUMINURIA AND RENAL PATHOLOGICAL CHANGES IN DIABETIC NEPHROPATHY RATS

LOW MOLECULAR WEIGHT HEPARIN DECREASES THE ALBUMINURIA AND RENAL PATHOLOGICAL CHANGES IN DIABETIC NEPHROPATHY RATS
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摘要 Objective To investigate the renoprotection effect of low molecular weight heparin(LMWH)in diabetic rats.Methods Diabetic rats were induced by injection of steptozotocin(STZ).Rats were randomly divided into three groups:control group,diabetic model group,and LMWH treatment group.The levels of total cholesterol(TC),triglyceride(TG),prothrombin time(PT),kaolin partial thromboplastin time(KPTT),24-hour urinary albumin excretion rate(UAER),and serum soluble P-selectin were determined after 8 weeks.Glomerular morphology was observed by light microscopy.Results The levels of TG,UAER,and P-selectin in LWMH treatment group were lower than those in model group(all P<0.01).The levels of PT and KPTT in LWMH treatment group were shorter than those in model group.And LWMH improved the histological changes of diabetic rats.Conclusion LMWH has some renal protective effects in diabetic rats,partly through down-regulating the expression of P-selectin. Objective To investigate the renoprotection effect of low molecular weight heparin（LMWH）in diabetic rats.Methods Diabetic rats were induced by injection of steptozotocin（STZ）.Rats were randomly divided into three groups：control group,diabetic model group,and LMWH treatment group.The levels of total cholesterol（TC）,triglyceride（TG）,prothrombin time（PT）,kaolin partial thromboplastin time（KPTT）,24-hour urinary albumin excretion rate（UAER）,and serum soluble P-selectin were determined after 8 weeks.Glomerular morphology was observed by light microscopy.Results The levels of TG,UAER,and P-selectin in LWMH treatment group were lower than those in model group（all P〈0.01）.The levels of PT and KPTT in LWMH treatment group were shorter than those in model group.And LWMH improved the histological changes of diabetic rats.Conclusion LMWH has some renal protective effects in diabetic rats,partly through down-regulating the expression of P-selectin.
作者 王锋 邢涛 汪年松 晏春根
机构地区 Department of Nephrology Australian School of Advanced Medicine Department of Internal Medicine
出处 《Medical Bulletin of Shanghai Jiaotong University》 CAS 2010年第2期66-70,共5页 上海交通大学学报（医学英文版）
基金 Supported by the Scientific Research Project of Shanghai Municipal Health Bureau(2008Y034) the Natural Scientific Research Project of Shanghai(05ZR14086)
关键词 diabetic nephropathy heparin P-selectin 糖尿病大鼠 低分子量肝素 糖尿病肾病 病理改变 蛋白尿 肾脏 凝血酶原时间 低分子肝素
分类号 S858.23 [农业科学—临床兽医学] T-332 [一般工业技术]
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参考文献3

  • 1王锋,汪年松,喻明.P选择素与糖尿病肾病[J].中华糖尿病杂志（1006-6187）,2005,13(5):396-397. 被引量：28
  • 2Tong Zhou Wei Song Feng Wang Department of Nephrology,Ruijin Hospital,Shanghai Second Medical University,Shanghai 200025,China Jin-Lian Chen Department of Gastroenterology,Shanghai Sixth People’s Hospital,Shanghai 200233,China Ming-Jun Zhang Animal Laboratory,Ruijin Hospital,Shanghai Second Medical University,Shanghai 200025,China Pei-Hua Ni,Department of Biochemistry,Shanghai Second Medical University,Shanghai 200025 Jian-Guo Geng Institute of Biochemistry and Cell Biology,Shanghai 200030,China.Effect of N-desulfated heparin on hepatic/renal ischemia reperfusion injury in rats[J].World Journal of Gastroenterology,2002,8(5):897-900. 被引量：20
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二级参考文献30

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Medical Bulletin of Shanghai Jiaotong University
2010年 第2期

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