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Wnt信号通路抑制因子Dickkopf-3与肿瘤关系的研究进展 被引量：2

Progress in Relationship between Cancer and Dickkopf-3,an Antagonist of the Wnt Signaling Pathway
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摘要 Wnt信号通路(Wnt通路)是重要的细胞信号转导途径,在细胞的增殖、分化中发挥重要的作用。Wnt通路的异常与多种肿瘤的发生或转移有关。研究发现Wnt拮抗剂Dkk-3(Dickkopf-3)可以拮抗Wnt通路,并与多种肿瘤相关,抑制Dkk-3可抑制肿瘤生长。因此,深入研究Dkk-3对肿瘤机制阐明和治疗具有重要意义。 The Wnt signaling pathway is an important cell signal way,which plays roles in cell proliferation and differentiation.Studies revealed that the abnormalities in Wnt signaling pathway often happened in many cancers.Dickkopf-3（Dkk-3）,an antagonist of the Wnt signaling pathway,may play roles in many cancers.By inhibiting Dkk-3,the growth of cancer cells were inhibited.It is valuable to study Dkk-3 for the further research of cancer.Therefore,the research on Dkk-3 is very important to understand the occurrence of tumor and its treatment.
作者 蔡敏 曹勇
机构地区 湖北省肿瘤医院 华中科技大学同济医院
出处 《医学综述》 2010年第24期3711-3712,共2页 Medical Recapitulate
关键词 WNT Dkk-3 肿瘤 Wnt Dickkopf-3 Cancer
分类号 R730.5 [医药卫生—肿瘤]
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参考文献20

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共引文献1

同被引文献28

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医学综述
2010年 第24期

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