摘要
急性有机磷农药中毒是临床常见危重疾病。有机磷农药中毒的机制是神经系统胆碱酯酶活性受抑制,胆碱酯酶磷脂化,无法水解乙酰胆碱,导致乙酰胆碱蓄积,从而引起一系列中毒症状。但目前对毒物的清除(包括胃肠道及血液内),对抗胆碱酯酶蓄积、恢复胆碱酯酶活性的药物使用,机械通气等关键问题认识不充分,基层医院死亡率仍高。现就上述问题结合本科救治经验进行总结,以期对提高临床抢救成功率有所帮助。
Acute organophosphorus pesticide poisoning is a common clinical critical illness.Organophosphorus pesticide poisoning mechanism is the inhibition of cholinesterase activity in nervous system and the accumulation of acetylcholine caused by the phosphoesterified cholinesterase unable to hydrolyze,which leads to a series of toxicities.However,due to the defects in the elimination of toxicants from the gastrointestinal tract and blood against cholinesterase accumulation,medical recovery of cholinesterase activity,awareness of key issues such as mechanical ventilation,the mortality still remains high in primary care hospitals.This article summarizes the aforementioned issues,our rescue experience in aiming to improve the clinical success rate.
出处
《医学综述》
2010年第24期3763-3765,共3页
Medical Recapitulate
关键词
急性有机磷农药中毒
机制
治疗
Acute organophosphorus pesticide poisoning
Mechanism
Treatment
