摘要
目的探讨自体外周血干细胞对肝硬化患者的治疗作用。方法选择肝硬化失代偿期患者35例,在内科综合治疗的基础上予自体外周血干细胞治疗作为A组,常规治疗20例作为对照组(B组)。A组经肝动脉将细胞悬液移植入肝脏,分别在治疗后第8周观察肝脏功能、临床症状及不良反应情况。结果 A组在治疗后第8周血浆白蛋白、胆碱酯酶明显升高,血清谷丙转氨酶、总胆红素水平下降,凝血指标好转,与对照组比较有显著性差异;临床症状和体征示:腹胀减轻30例(85.7%),食欲改善32例(91.4%),体力好转29例(82.9%),有腹水、胸水25例,减轻23例(92.0%)。在全部35例患者中未发生严重并发症,近期无不良反应出现。结论自体外周血干细胞治疗失代偿期肝硬化安全有效且副作用小,可作为肝硬化患者的临床治疗方案。
Objective To explore the efficiency of autologous peripheral blood stem cell in treatment of decompensated cirrhosis. Methods Fifty five patients with decompensated cirrhosis were randomly divided into treatment group （ n = 35 ） and control group （ n = 20 ） , the patients in the treatment group received autologous peripheral blood stem cell （after isolation and purification, the stem cells were transplanted into the liver via hepatic artery） based on the combined internal medicine therapy, and the con- trol group received the conventional therapy. After transplantation, the clinical symptoms and laboratory data were recorded at the eighth week. ResultS Eight weeks after transplantation,levels of albumin and eholinesterase increased. Alanin amino transferase and total bilirubin level decreased, Prothrombin time decreased, and the difference between the two groups had statistical signifi- cant（P 〈0. 05）. Abdominal distention was alleviated in 30 cases（85.7% ）, appetite was improved in 32 cases（91.4% ） and physical strength was improved in 29 cases（82.9% ） ,pleural and ascites was decreased in 23 cases（92.0% ）. No significant side effect was observed in the treatment group. Conclusion This therapy with autologous peripheral blood stem cell transplantation was safe and effective for the decompensated cirrhosis.
出处
《中华全科医学》
2011年第1期29-30,共2页
Chinese Journal of General Practice
关键词
自体
外周血
干细胞
肝硬化
Autologous
Peripheral blood
Stem cells
Cirrhosis
