摘要
目的比较地佐辛、芬太尼、芬太尼联合曲马多用于全子宫切除术后静脉镇痛的效果及不良反应。方法将60例择期行全子宫切除全麻患者,随机分为地佐辛组(D组)、芬太尼组(F组)及芬太尼联合曲马多组(FT组)三组,分别以地佐辛0.8 mg/kg,芬太尼0.016 mg/kg,芬太尼0.008 mg/kg联合曲马多6.5 mg/kg持续静脉镇痛。记录并比较术后48 h内视觉模拟疼痛(VAS)评分、Ramsay评分及不良反应。结果三组术后镇痛效果VAS组内比较差异无统计学意义。术后6 h、12 h D组VAS评分均明显低于FT组(P<0.05)。术后0.5 h6、h1、2 h D组Ramsay评分均明显高于F组(P<0.05)。术后D组恶心呕吐发生率明显低于FT组(P<0.05)。结论地佐辛0.8 mg/kg术后静脉镇痛效果优于芬太尼0.016 mg/kg和芬太尼0.008 mg/kg联合曲马多6.5 mg/kg,不良反应发生率较低。
Objective To compare the efficiency and side effects of postoperative analgesia with dezocine,fentanyl and fentanyl combined with tramdol. Methods Sixty patients underwent hysterectomy under general anesthesia were randomly assigned into 3 groups with 20 cases each. For postoperative intravenous analgesia, dezocine 0.8 mg/kg was given in group D, fentanyl 0.016 mg/ kg in group F and fentanyl 0. 008 mg/kg combined with Tramadol 6.5 mg/kg in group FT. The VAS analgesic score, Ramsay sedative score were recorded within 48 hours after operations. The side effects were evaluated as well. Results There were no significant differences in VAS scores among 3 groups. The VAS scores of group D were much lower than those of group FY at 6 h and 12 h after operation（ P 〈 0.05 ）. The Ramsay scores of group D were higher than those of group F at 0.5,6 and 12 h after operation （ P 〈 0.05 ）. The incidence of postoperative nausea and vomiting of group D was lower than that of group FT（ P 〈 0. 05 ）. Conclusion Demcine 0. 8 mg/kg is better than fentanyl 0. 016 mg/kg and fentanyl 0.008 mg/kg combined with tramadol 6.5 mg/kg for postoperative intravenous analgesia with fewer side effects in patients underwent hysterectomy.
出处
《中华全科医学》
2011年第1期31-31,98,共2页
Chinese Journal of General Practice
关键词
术后镇痛
地佐辛
芬太尼
曲马多
Postoperative analgesia
Dezocine
Fentanyl
Tramadol
