摘要
目的探讨慢性乙型肝炎应用干扰素联合微卡治疗的作用机制及疗效，方法按诊断标准选择慢性乙型肝炎患者160例．随机分为干扰素联合微卡为治疗组（80例）和干扰素为对照组（80例），观察比较两组患者肝功能、HBeAg及HBVDNA的变化，，结果治疗组的肝功能复常率、HBeAg及HBVDNA阴转率均明显高于对照组（P〈0.05）。结论干扰素联合微卡治疗慢性乙型肝炎有协同作用．它能提高细胞免疫应答能力，促进HBeAg及HBVDNA的阴转、减少病毒的变异，延迟耐药性的发生。
Objective To study the effects of interferon combined with M. Vaccae in the treatment of chronic B.Method These cases were divided into two groups randomly, treatment group of 80 cases received interferon combined with M. Vaccae and control group of 80 cases reeeived interferon. We observed of ransaminase, HBeAg and HBV DNA. Results The reovery ratc of transaminase of treatment group was higher than that of control group, and differences were significant between two groups （P〈0.05）. Conclusion There is a cooperative effect with interferon combined with M. Vaccae to treat chronic hepatitis B. It can improve cellular immune function, make HBeAg and HBV DNA change negative, decrease mutation of virus genotype, delay resistance of drugs.
作者
施于兴
杨君
罗斯广
SHI Yu-xing, YANG Jun, LUO Si-guang （1.CDC Centers for Disease Control and Prevention in Bazhou area of Bazhong city in Sichuan province;2.The second people hospital in Bazhou area of Bazhong city in Sichuan province,Bazhong 636000,China）
出处
《医学信息》
2011年第1期60-62,共3页
Journal of Medical Information
